3-Bromo-6-methoxypyridazine(CAS#17321-29-8)

Introduction

3-Bromo-6-methoxypyrazine is an organic compound. The following is a detailed introduction to its properties, uses, manufacturing methods and safety information:Quality:- Appearance: Colorless crystals or white crystalline powder.- Solubility: Soluble in ethanol, ether and chloroform.Use:3-Bromo-6-methoxypyrazine is mainly used as an intermediate in organic synthesis and has a wide range of applications:- As a pesticide intermediate, it is used in the synthesis of pesticides such as pyrethrin.- Catalysts or reagents used in organic synthesis reactions in the field of chemical research.Method:The common preparation method of 3-bromo-6-methoxypyrazine is obtained by bromination reaction of the corresponding pyrazine compound:Under appropriate reaction conditions, pyrazine compounds are reacted with ethyl bromide or chlorobromidomethane to produce 3-bromopyrazine or 3-chloropyrazine.Then, 3-bromopyrazine or 3-chloropyrazine is reacted with methanol to produce 3-bromo-6-methoxypyrazine by substitution.Safety Information:- 3-Bromo-6-methoxypyrazine is an organobromine compound and has some toxicity. Wear appropriate personal protective equipment during handling and avoid direct contact with skin and inhalation of gases or solutions.- During storage and handling, care should be taken to prevent high temperatures, ignition sources and strong oxidants.- Try to operate in a well-ventilated environment and avoid inhaling harmful gases.- In case of accidental contact, rinse immediately with plenty of water and consult a doctor.

Application
3-Bromo-6-methoxypyridazine (CAS 17321-29-8) is a versatile heterocyclic building block widely used in medicinal chemistry and drug discovery. The bromine at the 3-position enables efficient palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) for introducing diverse aryl, heteroaryl, or alkyl groups, while the methoxy group at the 6-position provides electronic modulation and metabolic stability. This scaffold serves as a key intermediate for the synthesis of potent kinase inhibitors targeting cancer, inflammation, and autoimmune diseases, including JAK, BTK, and PI3K inhibitors. It is also utilized in the development of antiviral, antibacterial, and antifungal agents. Its pyridazine core enhances target binding affinity and facilitates structure-activity relationship (SAR) studies. High purity ensures reproducible results in high-throughput screening and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this compound with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.