2-AMINO-5-BROMO-3-MORPHOLIN-4-YLPYRAZINE(CAS#117719-17-2)
Introduction
2-Amino-5-bromo-3-morpholino-4-pyrazine is an organic compound that contains a 2-amino group, a 5-bromogroup, a 3-morpholino, and a 4-ylpyrazine group in its chemical structure. The following is an introduction to its properties, uses, manufacturing methods and safety information:Quality:- Appearance: Colorless or light yellow crystals- Solubility: It has a low solubility in water but can be dissolved in organic solvents such as ethanol and dimethyl sulfoxideUse:- Chemical reagents: 2-amino-5-bromo-3-morpholino-4-ylpyrazine is commonly used as an intermediate and reagent in organic synthesis. They may have biological activities such as antitumor, anti-inflammatory, and antibacterial.- Pesticide research: The compound and its derivatives are also used as a basis for the study of pesticides.Method:The preparation method of 2-amino-5-bromo-3-morpholino-4-ylpyrazine can be achieved through synthesis strategies, such as carbon and nitrogen chemical synthesis and hydrogenation synthesis.Safety Information:- When handling this compound, follow laboratory safety procedures and wear necessary safety equipment such as lab gloves and goggles.- It may be irritating to the eyes, skin, and respiratory tract and requires avoiding direct contact.- It should be kept in a dry, dark and well-ventilated place, away from fire and flammable materials.
Application
2-Amino-5-bromo-3-morpholin-4-ylpyrazine (CAS 117719-17-2) is a highly functionalized pyrazine derivative used as a key intermediate in medicinal chemistry and drug discovery. The presence of an amino group, a bromine atom, and a morpholine ring on the pyrazine core enables diverse chemical transformations: the bromine facilitates Suzuki-Miyaura and Buchwald-Hartwig cross-coupling reactions, while the amino group allows amide and urea formation, and the morpholine enhances solubility and pharmacokinetic properties. This scaffold is widely employed in the synthesis of potent kinase inhibitors targeting cancer, inflammation, and autoimmune diseases, including PI3K, mTOR, and CDK inhibitors. It also serves as a building block for antiviral, antibacterial, and antifungal agents. The rigid pyrazine core provides metabolic stability and optimal target binding. High purity ensures reproducible results in SAR studies and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
