5-bromo-3-ethynylpyrazin-2-amine(CAS#1209289-08-6)
Introduction
5-Bromo-3-ethynylpyrazine-2-amine is an organic compound. The following is an introduction to some of its properties, uses, manufacturing methods and safety information:Quality:- Appearance: Yellow solid- Solubility: Soluble in some organic solvents such as dimethyl sulfoxide (DMSO), methylene chloride and ethanol.Use:- 5-Bromo-3-ethynylpyrazine-2-amine can be used in organic synthesis reactions.- It can be used as a ligand for organometallic catalysts and participate in organic synthesis reactions such as hydrogenation and coupling reactions.Method:- 5-Bromo-3-ethynylpyrazine-2-amine can be synthesized by a series of chemical reactions, such as direct substitution and coupling.Safety Information:- The safety information related to 5-bromo-3-ethynylpyrazine-2-amine has not been fully reported and should be used and handled with caution.- It may have irritating and damaging effects on the eyes, skin, and respiratory system, and contact should be avoided during operation.- Wear appropriate protective gear, including eyes and gloves, during use.- Follow safe laboratory operating procedures and follow basic principles for proper handling and storage of chemicals when operating.
Application
5-Bromo-3-ethynylpyrazin-2-amine (CAS 1209289-08-6) is a multifunctional heterocyclic building block combining a reactive bromine, an ethynyl group, and a free amine on the pyrazine core. As a privileged scaffold for drug discovery, this compound enables sequential cross-coupling (Suzuki-Miyaura, Sonogashira) and amide bond formation, allowing rapid construction of complex, drug-like libraries for SAR studies. Key applications in medicinal chemistry include the synthesis of kinase inhibitors (targeting cancer, inflammation), antiviral agents (HCV, HIV), and potent antibacterial compounds. The ethynyl group facilitates "click chemistry" bioconjugation and alkyne-azide cycloaddition reactions. Moreover, 5-bromo-3-ethynylpyrazin-2-amine serves as a versatile ligand for organometallic catalysts and participates in hydrogenation and coupling reactions in organic synthesis. Its applications span crop protection chemistry (herbicide/fungicide development), fluorescent probes, and functional materials. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this key API intermediate from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.
