3-bromo-5-chloropyridine-2-carbonitrile(CAS#760207-83-8)
Introduction
It is an organic compound with the chemical formula C6H2BrClN2. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: It is a solid with white to light yellow crystals.
-Solubility: It is soluble in some polar solvents (such as alcohols, ethers and dimethylformamide).
-Melting point and boiling point: Its melting point is about 85-87°C.
-Chemical properties: It can be used as a ligand to participate in reactions such as chloride and bromide, and can be used in organic synthesis reactions.
Use:
-It can be used as an intermediate in organic synthesis for the synthesis of other drugs, pesticides and chemicals.
-It can also be used to synthesize natural products and other organic compounds containing pyridine structure.
Preparation Method:
It can be synthesized by the following steps:
1. In dichloromethane or chloroform, 2-cyano -3-bromine pyridine and silver chloride reaction, the formation of silver salt.
2. The above silver salt is reacted with trifluoroacetic acid in dichloromethane to generate phosphonium.
Safety Information:
-should be stored in a cool, dry place, away from direct sunlight and moisture.
-During operation, wear appropriate protective equipment, such as gloves, glasses and laboratory coats, to avoid contact with skin and eyes.
-Observe relevant safe operation guidelines during storage and handling, and follow local regulations and codes.
Application
3-Bromo-5-chloropyridine-2-carbonitrile (CAS 760207-83-8) is a multifunctional heteroaryl halide widely used as a key building block in medicinal chemistry and agrochemical research. The bromine and chlorine atoms at positions 3 and 5 enable orthogonal, sequential palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) as well as nucleophilic aromatic substitution, while the nitrile group at the 2-position serves as a versatile handle for further functionalization (e.g., reduction to amine, conversion to amide or tetrazole). This scaffold is essential for the synthesis of selective kinase inhibitors targeting cancer, inflammation, and autoimmune diseases, as well as antiviral, antibacterial, and antifungal agents. It also serves as a key intermediate for the preparation of substituted pyridine-based drug candidates and agrochemicals (herbicides, fungicides). Its high purity ensures reproducible results in high-throughput screening, SAR studies, and scalable GMP manufacturing. Xinchem offers reliable custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.
