3,5-Dibromoanisole(CAS#74137-36-3)
| Hazard Symbols | T - Toxic |
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| Hazard Class | 6.1 |
| Packing Group | Ⅲ |
Introduction
3,5-Dibromoanisole(3,5-Dibromoanisole) is an organic compound with the chemical formula C7H6Br2O. Its appearance is colorless crystals or white crystalline powder.
In terms of properties, 3,5-Dibromoanisole is poorly soluble in water, but soluble in organic solvents such as alcohols and ethers. It has the characteristics of phenol, and the chemical reaction of phenol can occur under acidic conditions.
In terms of use, 3,5-Dibromoanisole is often used as a reaction intermediate in organic synthesis. It can participate in a series of chemical reactions, such as reaction with sulfuric acid to obtain the corresponding sulfuric acid ester, reaction with ammonium chloride to obtain the corresponding chlorophenyl ether.
Regarding the preparation method, a common preparation method is to dissolve p-dibromoanisole in acetonitrile, and then add sodium iodide under alkaline conditions to react to generate 3,5-Dibromoanisole.
In terms of safety information, 3,5-Dibromoanisole is toxic and may be harmful to the environment. During use, it should be noted that it is irritating to the skin and eyes, and avoid inhaling its powder or steam. During storage and handling, good ventilation should be paid attention to and contact with oxidants and strong acids should be avoided. At the same time, storage, transportation and handling should be carried out in accordance with relevant regulations.
Application
3,5-Dibromoanisole is a versatile halogenated aromatic building block used in the synthesis of pharmaceuticals, agrochemicals, and advanced materials. The two bromine atoms at the meta positions enable selective palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) to construct biaryl and heteroaryl scaffolds. The methoxy group can be demethylated to a phenol or further functionalized, offering additional versatility. This intermediate is widely employed in medicinal chemistry for the synthesis of kinase inhibitors, antiviral agents, and antibacterial drug candidates. In agrochemical research, it serves as a key precursor for herbicides, fungicides, and insecticides with improved efficacy and environmental profiles. It also finds applications in the production of liquid crystal display (LCD) materials, organic light-emitting diodes (OLEDs), fluorescent dyes, and specialty polymers. High purity ensures reproducible results in high-throughput screening, structure-activity relationship (SAR) studies, and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 3,5-dibromoanisole with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
