2-BROMO-3-METHYLPYRAZINE(CAS#120984-76-1)

Introduction

2-Bromo-3-methylpyrazine is an organic compound with the chemical formula C6H6BrN3. The following is an introduction to its nature, use, preparation and safety information:

Nature:

2-Bromo-3-methylpyrazine is a colorless to pale yellow crystal with a special odor. It is a potentially toxic compound that is irritating to the skin, eyes and respiratory tract.

Use:

2-Bromo-3-methylpyrazine has a wide range of applications in the field of agriculture. It can be used as a raw material for herbicides, fungicides and pesticides, and used to control weeds, pathogens and pests that are common in agricultural production. In addition, in the field of medicine, it can also be used as an intermediate for certain drugs.

Method:

There are many ways to prepare 2-bromo -3-methyl pyrazine, and the commonly used method is obtained by bromination of 2-pyrazine formaldehyde. High purity products can be prepared by following the principles and techniques of synthetic chemistry.

Safety Information:

2-Bromo-3-methylpyrazine is a toxic compound and should be handled with care. Appropriate protective measures should be taken during use or operation, such as wearing chemical glasses, gloves and suitable protective clothing. Avoid direct contact with skin, avoid breathing gas or dust. Ensure good ventilation during operation. If you come into contact with the compound, immediately flush the affected area with clean water and seek medical attention. In addition, it should be stored away from fire and oxidizing agents, and stored in a dry, ventilated place.

Application
2-Bromo-3-methylpyrazine (CAS 120984-76-1) is a key heterocyclic building block widely used in medicinal chemistry and drug discovery. The bromine at the 2-position enables efficient palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) for introducing diverse aryl, heteroaryl, or alkyl groups, while the methyl group at the 3-position provides steric and electronic modulation. This scaffold serves as a versatile intermediate for synthesizing kinase inhibitors targeting cancer (e.g., JAK, BTK, CDK), antiviral agents, and antibacterial compounds. Its pyrazine core offers excellent metabolic stability and target binding affinity, facilitating rapid structure-activity relationship (SAR) studies. The compound is also utilized in agrochemical research for developing herbicides and fungicides. High purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of 2-bromo-3-methylpyrazine with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.