(Chloromethyl)pyrazine(CAS#39204-47-2)
Introduction
2-Chloromethylpyrazine is an organic compound. The following is an introduction to the properties, uses, preparation methods and safety information of 2-chloromethylpyrazine:Quality:- Appearance: 2-Chloromethylpyrazine is a colorless to light yellow liquid.- Solubility: It can be dissolved in water and most organic solvents.Use:- Pesticides: It can also be used as a raw material for insecticides and herbicides.- Laboratory research: 2-chloromethylpyrazine can be used as a reagent in organic synthesis.Method:2-Chloromethylpyrazine is usually prepared by the following steps:2-Pyrazine formaldehyde is reacted with chloromethane to form an intermediate of 2-chloromethylpyrazine.The intermediates were further reacted and purified to obtain the final product, 2-chloromethylpyrazine.Safety Information:- 2-Chloromethylpyrazine is a flammable liquid and should be kept away from open flames and high temperatures.- Wear appropriate personal protective equipment (PPE) such as chemical gloves, goggles, etc. during use.- Avoid inhaling vapors or contact with skin and eyes.- Waste disposal should be carried out in accordance with local regulations and should not be dumped indiscriminately.
Application
(Chloromethyl)pyrazine (CAS 39204-47-2) is a versatile alkylating reagent featuring a reactive chloromethyl group attached to a pyrazine ring. This heterocyclic building block is widely used in medicinal chemistry and pharmaceutical research for the synthesis of bioactive molecules, including kinase inhibitors, antiviral agents, and antimicrobial compounds. The chloromethyl group enables efficient nucleophilic substitution reactions with amines, thiols, alcohols, and carboxylates, allowing rapid introduction of the pyrazinylmethyl moiety into drug candidates. It also serves as a key intermediate for the preparation of pyrazine-containing ligands, metal complexes, and agrochemicals. The compound's high reactivity facilitates structure-activity relationship (SAR) studies and library construction in drug discovery. High purity ensures reproducible results in high-throughput screening and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity (chloromethyl)pyrazine with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
