1-Fluoro-2-nitrobenzene(CAS#1493-27-2)

Introduction

2-Fluoronitrobenzene is an organic compound. The following is an introduction to some of the properties, uses, preparation methods and safety information of 2-fluoronitrobenzene:Quality:- Appearance: Colorless crystals- Solubility: Soluble in organic solvents such as ethanol, ether and benzeneUse:- 2-fluoronitrobenzene is widely used in the field of organic synthesis.- 2-Fluoronitrobenzene can also be used as a raw material for high-explosive products such as gunpowder and explosives.Method:- There are many ways to prepare 2-fluoronitrobenzene, one of which is to react 2-aminofluorobenzene with nitric acid to generate 2-fluoronitrobenzene under appropriate conditions.Safety Information:- 2-Fluoronitrobenzene is dangerous and should be handled with caution.- During operation, good ventilation should be ensured and inhalation of gases and vapors should be avoided.- When exposed to 2-fluoronitrobenzene, wear appropriate chemical protective gloves and eye protection.

Application
1-Fluoro-2-nitrobenzene (o-fluoronitrobenzene) is a versatile aromatic building block widely used as a pharmaceutical intermediate and agrochemical precursor. The fluorine atom, activated by the ortho-nitro group, readily undergoes nucleophilic aromatic substitution (SNAr) with amines, alkoxides, and thiols, enabling efficient synthesis of substituted anilines, ethers, and thioethers. In drug discovery, it is a key starting material for fluoroquinolone antibiotics (e.g., norfloxacin, ciprofloxacin), antifungal agents, and anticancer compounds. In agrochemistry, it serves as a precursor for selective herbicides, fungicides, and insecticides. It is also employed in the production of dyes, liquid crystal displays (LCDs), and specialty polymers. High purity ensures reproducible results in SNAr reactions, cross-coupling, and reduction to 2-fluoroaniline. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.