4-Chloro-2-fluorobenzaldehyde(CAS#57381-51-8)
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/38 - Irritating to eyes and skin. |
| Safety Description | S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | 3439 |
| HS Code | 29269090 |
| Hazard Note | Toxic |
| Hazard Class | 6.1 |
| Packing Group | III |
Introduction
It is an organic compound with the chemical formula C7H3ClFN. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: Colorless or pale yellow crystalline solid.
-Solubility: Good solubility in organic solvents, such as ethanol, dimethyl sulfoxide, etc.
-Melting point: about 66-69°C.
-Boiling point: about 254°C.
-Density: about 1.47g/cm³.
-Stability: relatively stable to heat and light.
Use:
-It can be used as an intermediate in organic synthesis and used in the production of pharmaceuticals, pesticides and other chemicals.
-can be used as derivatives of aromatic compounds synthesis.
Preparation Method:
Synthesized generally by the following steps:
1. reacting p-chlorobenzaldehyde with cyanide to obtain p-chlorobenzaldehyde cyanide intermediate.
2. The intermediate will react with silver fluoride to obtain the product.
Safety Information:
-is an organic compound that may cause irritation and harm to the human body.
-Avoid contact with skin, eyes and respiratory tract, and rinse with plenty of water in time.
-During operation and storage, good ventilation measures should be taken to avoid inhalation of its vapors.
-Use personal protective equipment such as gloves and goggles.
-If you have ingested or inhaled large amounts of this compound, please seek medical attention.
Application
4-Chloro-2-fluorobenzaldehyde (CAS 57381-51-8) is a versatile halogenated benzaldehyde widely used as a key intermediate in organic synthesis. In pharmaceutical research and development, it serves as a crucial building block for the synthesis of various active pharmaceutical ingredients (APIs), including PCSK9 inhibitors for cholesterol management, antihypertensive agents, anti-inflammatory drugs, and anticancer therapeutics. In agrochemistry, this compound is an essential precursor for the production of herbicides, pesticides, and fungicides. It is also employed in the synthesis of diverse heterocyclic scaffolds such as pyrazoles, pyridazines, pyrimidines, and triazoles, which are core structures in drug discovery. Beyond life sciences, 4-chloro-2-fluorobenzaldehyde is utilized as an intermediate for azo dyes, specialty polymers (poly(aryl ether)s), and liquid crystal materials. Its dual halogen substitution pattern (chlorine and fluorine) enables regioselective functionalization and cross-coupling reactions, making it a valuable scaffold for structure-activity relationship studies. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 4-chloro-2-fluorobenzaldehyde with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
![2-(2 2-difluorobenzo[d][1 3]dioxol-5-yl)acetonitrile（CAS# 68119-31-3)](https://www.xinchem.com/uploads/222difluorobenzod13dioxol5ylacetonitrile.png)
