4-Chloro-2-fluorobenzaldehyde(CAS#61072-56-8)
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R22 - Harmful if swallowed |
| Safety Description | S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37 - Wear suitable gloves. |
| TSCA | T |
| HS Code | 29130000 |
| Hazard Note | Irritant |
| Hazard Class | IRRITANT, AIR SENSIT |
Introduction
4-Chloro-2-fluorobenzaldehyde is an organic compound. The following is an introduction to the properties, uses, preparation methods and safety information of 4-chloro-2-fluorobenzaldehyde:Quality:4-Chloro-2-fluorobenzaldehyde is a colorless to light yellow liquid. It has a special aroma and is soluble in most organic solvents. The compound is stable in air.Use:4-chloro-2-fluorobenzaldehyde has important application value in the field of organic synthesis. It can also be used in the synthesis of organic synthesis reagents, polymers, and coatings.Method:The preparation method of 4-chloro-2-fluorobenzaldehyde is mostly obtained by the reaction of fluorochlorobenzaldehyde and the corresponding fluorochlorocompounds. The specific preparation method can be adjusted according to the specific needs.Safety Information:The compound can be irritating and direct contact with the skin, eyes, and mucous membranes should be avoided.Personal protective equipment such as protective gloves, glasses, and protective clothing should be worn when in use.Avoid reacting with strong oxidants and strong acids to avoid the production of dangerous substances.Use in a well-ventilated area and avoid inhaling its vapors.
Application
4-Chloro-2-fluorobenzaldehyde (CAS 61072-56-8) is a versatile halogenated benzaldehyde building block widely used as a key intermediate in organic synthesis. In pharmaceutical development, it serves as an important precursor for the synthesis of various bioactive compounds, particularly anti-cancer agents and anti-inflammatory drugs. The reactive aldehyde group enables the construction of diverse heterocyclic scaffolds—including benzimidazoles, benzotriazoles, quinoxalinones, and benzodiazepinediones—that are valuable pharmacophores in medicinal chemistry. Schiff base metal complexes derived from this compound have demonstrated promising antibacterial activity against both Gram-negative and Gram-positive bacteria. In agrochemical research, it plays a role in the formulation of effective pesticides, herbicides, and fungicides. Material science applications include its use as a precursor for synthesizing poly(aryl ether)s, which exhibit high thermal stability for aerospace and electronics applications. This compound is also utilized in analytical chemistry as a reference standard for chromatographic identification and quality control. Its unique 4-chloro-2-fluoro substitution pattern enables regioselective functionalization, supporting rapid structure-activity relationship studies and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 4-chloro-2-fluorobenzaldehyde with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
