4-Methylbenzyl chloride(CAS#104-82-5)
| Risk Codes | R34 - Causes burns R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S27 - Take off immediately all contaminated clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S37/39 - Wear suitable gloves and eye/face protection |
| UN IDs | UN 2922 8/PG 3 |
| WGK Germany | 1 |
| RTECS | ZE4030000 |
| FLUKA BRAND F CODES | 19 |
| TSCA | Yes |
| HS Code | 29036990 |
| Hazard Note | Harmful/Corrosive/Lachrymatory |
| Hazard Class | 8 |
| Packing Group | III |
Introduction
Methyl chloride is an organic compound. It is a colorless liquid with a special aromatic odor. The following is an introduction to the properties, uses, preparation methods and safety information of methyl chloride:Quality:Density: approx. 1.09 g/mL.Insoluble in water, but soluble in organic solvents.Use:Methyl tribenzyl chloride is a commonly used intermediate in chemical synthesis for the synthesis of other organic compounds.Method:There are many ways to prepare methylbenzyl chloride, and one of the commonly used methods is to prepare it by benzylation reaction. The specific steps are as follows:The chloromethane and phenyl magnesium solution are reacted to form benzylmagnesium chloride, which is then reacted with styrene to obtain methyl chloride.Safety Information:Methyl chloride is an organic solvent that is toxic and irritating to the skin and eyes.Wear appropriate protective gloves and goggles when using to avoid contact with skin and eyes.Good ventilation should be ensured during operation and inhalation of its vapours should be avoided.Avoid contact with strong oxidizing agents and strong acids to avoid dangerous reactions.
Application
4-Methylbenzyl chloride (CAS 104-82-5) is a key alkylating agent widely used in the synthesis of active pharmaceutical ingredients (APIs), particularly for analgesics and anti-inflammatory drugs. It serves as a versatile pharmaceutical intermediate and fine chemical raw material. In agrochemicals, it is employed to produce selective herbicides and pesticides, while in the fragrance industry, it contributes to aromatic flavoring agents. The compound is also crucial for preparing polymer resins, dyes, and photoinitiators. Its reactive chloromethyl group enables nucleophilic substitution and cross-coupling reactions, facilitating the derivatization to valuable intermediates such as p-methylbenzyl alcohol and p-methylbenzaldehyde. Additionally, it is used in the manufacture of p-tolylacetic acid and other specialty fine chemicals. Xinchem offers flexible custom synthesis and contract manufacturing of high‑purity 4‑methylbenzyl chloride, scaled reliably from R&D to commercial tons. Contact us for a competitive quote and global supply.




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