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1-Fluoro-2-iodobenzene(CAS#348-52-7)

Chemical Property:

Molecular Formula C6H4FI
Molar Mass 222
Density 1.903g/mLat 25°C(lit.)
Melting Point −41-−40°C(lit.)
Boling Point 188-189°C(lit.)
Flash Point 160°F
Vapor Presure 0.791mmHg at 25°C
Appearance Liquid
Specific Gravity 1.903
Color Clear light yellow
BRN 2039770
Storage Condition Keep in dark place,Inert atmosphere,Room temperature
Sensitive Light Sensitive
Refractive Index n20/D 1.59(lit.)

Product Detail

Product Tags

Risk Codes R22 - Harmful if swallowed
R37/38 - Irritating to respiratory system and skin.
R41 - Risk of serious damage to eyes
R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S39 - Wear eye / face protection.
S61 - Avoid release to the environment. Refer to special instructions / safety data sheets.
S37/39 - Wear suitable gloves and eye/face protection
UN IDs UN3082 - class 9 - PG 3 - DOT NA1993 - Environmentally hazardous substances, liquid, n.o.s. HI: all (not BR)
WGK Germany 2
TSCA T
HS Code 29039990
Hazard Class IRRITANT

 

Introduction

O-fluoroiodobenzene is an organic compound. The following is a detailed introduction to the properties, uses, preparation methods and safety information of o-fluoroiodobenzene:- Properties:- Appearance: o-fluoroiodobenzene is a colorless or light yellow crystal. - Solubility: O-fluoroiodobenzene is easily soluble in organic solvents such as ethanol, ether and dimethylformamide. Uses:- O-fluoroiodobenzene can be used as a reagent in organic synthesis, such as participating in the formation of carbon-carbon bonds. - O-fluoroiodobenzene contains halogen atoms, which can be used as labeling reagents, mainly to track or label changes in compounds during chemical reactions. Preparation method:- One of the preparation methods of o-fluoroiodobenzene is to react bromobenzene with sodium fluoride and then treat the resulting product with a solution containing periodic acid. - Another preparation method is to first react p-fluoroiodobenzene and pyridine to form p-fluoroiodide, and then nitrate to obtain o-fluoroiodobenzene. Safety Information:- O-fluoroiodobenzene is an organic compound, precautions should be taken when in contact to avoid direct contact with the skin and eyes. - Inhalation or ingestion of o-fluoroiodobenzene may be harmful to health, and inhalation of its dust or solution should be avoided and ingestion should be avoided. - When using o-fluoroiodobenzene, it should be done in a well-ventilated area to avoid the accumulation of harmful gases. - In case of accidental exposure to or inhalation of o-fluoroiodobenzene, immediately move the victim to fresh air and seek medical assistance if necessary.

Application

1-Fluoro-2-iodobenzene (CAS 348-52-7) is a valuable ortho-substituted aryl halide widely used as a versatile building block in medicinal chemistry and organic synthesis. The iodine atom enables efficient palladium-catalyzed cross-coupling reactions including Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira, and Heck couplings, while the fluorine provides metabolic stability and modulates electronic properties. This compound serves as a key pharmaceutical intermediate for the synthesis of bioactive molecules such as kinase inhibitors, antiviral agents, and anti-inflammatory drugs. In agrochemical research, it is a precursor for modern herbicides and fungicides. Its unique ortho-fluoroiodo substitution pattern allows regioselective functionalization and rapid diversification of heterocyclic scaffolds. Additionally, it is employed in materials science for the preparation of organic semiconductors and liquid crystal displays. High-purity 1-fluoro-2-iodobenzene ensures reproducible results in high-throughput screening, SAR studies, and GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.


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