4-Pyrimidinol, 2-amino- (9CI)(CAS#100643-25-2)
Uses: It is a key intermediate in the design and synthesis of pyrimidine compounds, and is used as a reagent in biochemical research. Pyrimidine-containing high-efficiency and low-toxicity drugs have emerged in an endless stream, especially the backbone of isocytosine exists in the molecular structure of many antitumor drugs, such as acyclovir, gleevec, etc.
It should be noted that oral isocytosine is harmful to the human body and has an irritating effect on the eyes.
Uses: It is a key intermediate in the design and synthesis of pyrimidine compounds, and is used as a reagent in biochemical research. Pyrimidine-containing high-efficiency and low-toxicity drugs have emerged in an endless stream, especially the backbone of isocytosine exists in the molecular structure of many antitumor drugs, such as acyclovir, gleevec, etc.
It should be noted that oral isocytosine is harmful to the human body and has an irritating effect on the eyes.
2-Aminopyrimidin-4-ol (2-Amino-4-hydroxypyrimidine, isocytosine, CAS 100643-25-2) is a key heterocyclic building block in medicinal chemistry, valued as an isomer and close structural analog of the natural nucleobase cytosine. As a purine-like scaffold, its unique 2-amino-4-hydroxy substitution pattern makes it a privileged pharmacophore and pharmaceutical intermediate. It is primarily used in drug discovery to synthesize kinase inhibitors, antiviral agents, antibacterial compounds, and potential anticancer therapeutics. Functioning as a 2-aminopyrimidine derivative, it readily undergoes cross-coupling and nucleophilic substitution to enable rapid structure-activity relationship (SAR) studies and building block derivatization. Its isocytosine structure also makes it a critical research chemical for physical chemical studies, including metal complex binding, hydrogen-bonding investigations, and tautomerism effects in synthetic nucleobase systems. Xinchem is a leading manufacturer, supplier, and CDMO partner for 2-Aminopyrimidin-4-ol. We offer flexible custom synthesis, custom chemical synthesis, and reliable contract manufacturing, scaling from R&D samples to commercial tons. Contact us for a competitive quote and direct global supply.
