3-CHLOROPYRIDAZINE-4-CARBONITRILE(CAS#1445-56-3)

Introduction

Properties: 3-Chloropyridazine-4-formonitrile is an organic compound. It is a colorless to pale yellow crystalline solid that is soluble in organic solvents such as ethanol and dimethyl sulfoxide.Uses: 3-chloropyridazine-4-formonitrile is often used as an intermediate in chemical synthesis.Preparation method: The preparation method of 3-chloropyridazine-4-formonitrile is usually obtained by the reaction of pyridazine compounds with stannous chloride. Specifically, pyridazine compounds are reacted with stannous chloride in an organic solvent and purified by distillation to obtain the target product.It can have an irritating and corrosive effect on the human body and can cause eye and skin damage. Appropriate protective equipment such as gloves, glasses, and protective clothing should be worn during operation. When storing and disposing of them, follow relevant safe practices and avoid contact with oxidants or flammable materials.

Application
3-Chloropyridazine-4-carbonitrile (CAS 1445-56-3) is a functionalized heterocyclic building block featuring a chlorine atom at the 3-position and a nitrile group at the 4-position. It is widely used in medicinal chemistry and pharmaceutical research as a key intermediate for the synthesis of bioactive molecules, including kinase inhibitors, antiviral agents, and antibacterial compounds. The nitrile group enables further functionalization via reduction to amine or hydrolysis to carboxylic acid, while the chlorine allows nucleophilic aromatic substitution and cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig) for rapid structure-activity relationship (SAR) studies. This scaffold also serves as a precursor for phthalazine derivatives, which exhibit anticancer and anti-inflammatory activities. In agrochemical research, it is utilized in the development of herbicides and fungicides. High purity ensures reproducible results in high-throughput screening and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this versatile intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.