2-amino-5,5-dimethyl-4,6-dihydro-1,3-benzothiazol-7-one(CAS#1629-95-4)

Introduction

Properties: 2-Amino-5,5-dimethyl-5,6-dihydro-4H-benzothiazole-7-one is an organic compound. It is a white crystalline solid with a bitter taste. The compound has some stability, but it may react under the action of strong oxidants.Method: 2-amino-5,5-dimethyl-5,6-dihydro-4H-benzothiazole-7-one can be synthesized by synthesis.Safety information: The safety of 2-amino-5,5-dimethyl-5,6-dihydro-4H-benzothiazole-7-one is not very clear, and it is necessary to pay attention to safe operation when using it. Contact with eyes, skin, and mucous membranes should be avoided. During use, appropriate personal protective equipment should be worn, such as laboratory gloves, protective glasses, etc.

Application
2-Amino-5,5-dimethyl-4,6-dihydro-1,3-benzothiazol-7-one (DMABT, CAS 1629-95-4) is a specialized benzothiazole building block for drug discovery, valued for its fused heterocyclic architecture and a free primary amine. Its rigid, electron-rich 2-aminobenzothiazole scaffold is widely used in medicinal chemistry as a critical intermediate for synthesizing selective kinase inhibitors, including potent JAK3 inhibitors for autoimmune disease therapy. The gem-dimethyl group provides steric bulk, which improves metabolic stability and enhances specificity for biological targets such as cysteine proteases. Pharmacological studies indicate that DMABT-based derivatives also exhibit significant anticancer, antimicrobial, and anti-inflammatory activities, with particular promise against breast and colon cancer cell lines. Beyond pharmaceuticals, the compound is explored in agrochemical research for developing crop protection agents and in materials science for constructing fluorescent chemosensors. As a custom synthesis intermediate, it enables scalable SAR exploration and GMP-compliant production of targeted covalent inhibitors and CNS drug candidates. Xinchem offers reliable global supply of DMABT with flexible contract manufacturing from R&D to commercial tons. Contact us today.