4-Bromo-2-nitrobenzoic acid（CAS# 99277-71-1)

Introduction

4-Bromo-2-nitrobenzoic acid (CAS 99277-71-1) is a multifunctional halogenated nitrobenzoic acid that serves as a critical pharmaceutical intermediate and versatile building block. Its primary application is as a key precursor in the synthesis of Lonafarnib, a farnesyltransferase inhibitor with potential anticancer activity against certain leukemias and other cancers. The compound undergoes Negishi-type coupling with dimethylzinc under palladium-phosphine catalysis, a critical step in constructing the Lonafarnib scaffold. Beyond oncology, this anthranilic acid derivative functions as a radiolabel for the positron emission tomography (PET) diagnosis of bladder cancer, where its uptake in bladder tissue is proportional to cell number. As a versatile research chemical, it serves as a biochemical reagent and sulfonylation reagent for organic synthesis and drug discovery. Its utility extends to the synthesis of agrochemical compounds, dye intermediates, and substituted benzoic acid derivatives. The presence of bromine, nitro, and carboxylic acid groups allows for diverse functionalization via cross-coupling, reduction, and amidation reactions. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 4-Bromo-2-nitrobenzoic acid with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.