2-Amino-6-bromobenzothiazole(CAS#15864-32-1)

Introduction

2-Amino-6-bromobenzothiazole is an organic compound. The following is an introduction to some of its properties, uses, manufacturing methods and safety information:Quality:1. Appearance: 2-amino-6-bromobenzothiazole is a white or yellowish crystalline powder.3. Solubility: It has a certain solubility in common organic solvents.Use:1. Chemical reagent: 2-amino-6-bromobenzothiazole is often used as an intermediate in organic synthesis and can be used to synthesize other compounds.2. Pesticides: It is also used in the synthesis of pesticides in the agricultural field.Method:The preparation of 2-amino-6-bromobenzothiazole can be carried out by the following steps:1. Synthesis of precursor compounds of 2-amino-6-bromobenzothiazole.2. The precursor compound is reacted with the appropriate reagent to undergo cyclization, amination, or other reactions to obtain the target product.Safety Information:1. 2-Amino-6-bromobenzothiazole may have an irritating effect on the skin, eyes, and respiratory system, and should be avoided.2. Personal protective measures such as protective gloves, goggles and respiratory protective devices should be worn during use.3. It should be used in a well-ventilated place to avoid inhaling its aerosols or dust.4. In case of accidental ingestion or inhalation, seek medical attention immediately.

Application
2-Amino-6-bromobenzothiazole (CAS 15864-32-1) is a privileged heterocyclic building block extensively used in medicinal chemistry and drug discovery. Its rigid 2-aminobenzothiazole core with a bromine atom at the 6-position enables efficient cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) and nucleophilic substitutions, allowing rapid construction of diverse pharmaceutical libraries. This intermediate serves as a key precursor for the synthesis of potent kinase inhibitors targeting cancer (e.g., PI3K, CDK, and EGFR inhibitors), antiviral agents (including HIV-1 integrase inhibitors), and antibacterial compounds (e.g., against methicillin-resistant Staphylococcus aureus). Its derivatives have also shown promising anti-inflammatory, antitubercular, and antifungal activities. Additionally, 2-amino-6-bromobenzothiazole is utilized in the preparation of fluorescent probes for bioimaging, corrosion inhibitors, and functional materials. The free amino group permits acylation, alkylation, or urea formation, while the bromine allows orthogonal functionalization, facilitating structure-activity relationship (SAR) studies and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this high-purity intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.