5-Bromo-4-isopropylthiazol-2-amine(CAS#1025700-49-5)
Introduction
It is an organic compound. The following is an introduction to its nature, use, preparation and safety information:
Nature:
-Appearance: It is a solid compound, usually in the form of white crystals or crystalline powder.
-Solubility: It can be dissolved in many organic solvents, such as ethanol, dimethyl sulfoxide and chloroform.
Use:
-Chemical synthesis: It can be used as an intermediate in organic synthesis and used to synthesize other compounds, such as active ingredients in medicines and pesticides.
-Drug research: It can also be used as a reference compound in the field of drug research for research and development of new drugs.
Preparation Method:
-Br can be prepared by a variety of different synthetic methods, one of which is the reaction of propylthiophenol and 2-bromoacetonitrile in the presence of a base.
Safety Information:
-is a chemical item that needs to be handled and stored in a laboratory or suitable professional environment.
-When using, care must be taken to comply with safety practices, including wearing appropriate personal protective equipment, such as protective glasses, gloves and laboratory coats.
-It may have certain health hazards, including irritation and toxicity. Therefore, care must be taken when handling and avoid inhalation, ingestion or contact with skin and eyes.
-If inhaled or exposed to the compound, take immediate first aid measures and seek medical help.
Application
5-Bromo-4-isopropylthiazol-2-amine (CAS 1025700-49-5) is a functionalized heterocyclic building block widely used in medicinal chemistry and drug discovery. The bromine at the 5-position enables efficient palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) to introduce diverse aryl, heteroaryl, or alkyl substituents, while the free amino group allows acylation, alkylation, or urea formation. The isopropyl group at the 4-position provides steric and lipophilic modulation, enhancing metabolic stability and target selectivity. This scaffold serves as a key intermediate for the synthesis of potent kinase inhibitors targeting cancer, inflammation, and autoimmune diseases (e.g., JAK, BTK, CDK, and PI3K inhibitors). It is also utilized in the development of antiviral, antibacterial, and antifungal agents. Its rigid thiazole core offers excellent target binding affinity and pharmacokinetic properties. High purity ensures reproducible results in high-throughput screening, structure-activity relationship (SAR) studies, and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
