2-Chloro-1,3-thiazole-5-carboxylic acid(CAS#101012-12-8)
| Hazard Class | IRRITANT |
Introduction
2-Chloro-thiazole-5-carboxylic acid is an organic compound whose chemical formula is C4H2ClNO2S. The following is a description of the properties, uses, preparation and safety information of 2-chloro-thiazole-5-carboxylic acid:
Nature:
-Appearance: 2-Chloro-thiazole-5-carboxylic acid is a colorless to slightly yellow solid.
-Solubility: It is soluble in water and some organic solvents such as ethanol and ether.
-Stability: It is relatively stable at room temperature, but avoid prolonged exposure to sunlight and high temperature.
- pH value: The pH value of 2-chloro-thiazole-5-carboxylic acid is about 2.5.
Use:
-Pharmaceutical field: 2-Chloro-thiazole-5-carboxylic acid can be used as an intermediate for the synthesis of some drugs and biologically active compounds.
-Pesticide field: It is also used to prepare some pesticides, such as insecticides and fungicides.
Preparation Method:
-2-Chloro-thiazole-5-carboxylic acid can be obtained by reacting 2-chloro-5-nitrothiazole with formic acid.
Safety Information:
-2-Chloro-thiazole-5-carboxylic acid should be kept away from open flames and high temperatures, and avoid contact with skin, eyes and respiratory tract.
-Wear protective gloves, goggles and breathing apparatus when using.
-If touched, flush the affected area immediately with plenty of water and consult a doctor.
Application
2-Chloro-1,3-thiazole-5-carboxylic acid (CAS 101012-12-8) is a versatile heterocyclic building block used extensively in medicinal chemistry and drug discovery. The reactive chlorine at the 2-position enables nucleophilic aromatic substitution and palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) to introduce diverse amine, aryl, or alkyl groups. The carboxylic acid at the 5-position allows facile amide and ester formation, facilitating rapid structure-activity relationship (SAR) studies. This scaffold is a key intermediate for synthesizing potent kinase inhibitors targeting cancer, inflammation, and autoimmune diseases (e.g., PI3K, CDK, EGFR, and BTK inhibitors). It also serves as a precursor for antiviral, antibacterial, and antifungal agents. Its rigid, electron-deficient thiazole core enhances metabolic stability and target binding affinity. High purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
