2-Methoxy-5-(tributylstannyl)thiazole(CAS#1025744-42-6)
| Hazard Symbols | T - Toxic |
Introduction
2-Methoxy-5-(tributylstannyl)thiazole is an organic compound with the formula C15H27NOSn.
Properties: 2-Methoxy-5-(tributylstannyl)thiazole is a yellow to orange crystal or liquid with low solubility. It is a combination of inorganic tin and organic thiazole, with good thermal stability and photoelectric properties.
Uses: 2-Methoxy-5-(tributylstannyl)thiazole is an important material precursor, which can be used in organic synthesis reactions and the preparation of functional materials, such as optoelectronic materials, organic semiconductor materials, coatings and ligands.
Preparation Method: 2-Methoxy-5-(tributylstannyl)thiazole can be prepared by reacting a corresponding tin compound with a thiazole compound. The specific synthesis method can refer to the relevant literature or be prepared by a person skilled in the art.
Safety Information: The toxicity and safety studies of 2-Methoxy-5-(tributylstannyl)thiazole are relatively limited, so it is important to pay attention to the safe handling of chemicals during use, avoid contact with skin and eyes, and ensure that they are operated in a well-ventilated environment. If ingested or inhaled, seek medical help immediately. In the process of storage and handling, waste should be properly managed and disposed to ensure safety and environmental protection.
Application
2-Methoxy-5-(tributylstannyl)thiazole (CAS 1025744-42-6) is a high-purity heteroaryl stannane primarily used as an organotin building block in palladium-catalyzed Stille cross-coupling reactions. It facilitates the efficient construction of carbon-carbon bonds to incorporate the 2-methoxythiazol-5-yl moiety into complex (hetero)aromatic scaffolds. This makes it a key pharmaceutical intermediate for developing trisubstituted thiazole derivatives, which are extensively explored as selective inhibitors of Cdc7 kinase, a target for cancer therapy. It is also employed as a reactant in the synthesis of near-infrared (near-IR) BODIPY dyes, enabling bioimaging, sensing, and photovoltaic applications. The versatile thiazole core serves as a ligand on a variety of biological matrices. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this high-purity building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
