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1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic acid(CAS#156270-06-3)
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| HS Code | 29339980 |
| Hazard Class | IRRITANT |
Introduction
1H-Pyrrolo [2,3-b] Pyridine-3-Carboxylic acid is an organic compound with the chemical formula C12H8N2O2.
Nature:
1H-Pyrrolo [2,3-b] Pyridine-3-Carboxylic acid is a solid with a white crystalline form. It is a weak acid that can react with a base to form the corresponding salt. The compound is insoluble in water at normal temperature, but soluble in organic solvents such as chloroform, methanol and ethanol.
Use:
1H-Pyrrolo [2,3-b] Pyridine-3-Carboxylic acid is widely used as an intermediate in organic synthesis in the fields of medicine, pesticide and dye. It can be used for the synthesis of aminopyrimidine anticancer drugs, trifluoro chloropyrimidine and other drugs.
Method:
1H-Pyrrolo [2,3-b] Pyridine-3-Carboxylic acid has many preparation methods. A common method is through benzopyrrolo [2,3-b] pyridine-3, the 6-diketone is obtained by reaction with formic acid. Specific preparation methods can be found in the literature and chemical handbooks, as required.
Safety Information:
1h-yrrolo [2,3-b] The safety of Pyridine-3-Carboxylic acid is good, but necessary safety protection measures are still needed. Rinse immediately with water when in contact with skin. Wear chemical protective gloves and eye protection equipment when handling this compound. Avoid inhaling its dust or contact with food and drinking water. If necessary, it should be operated in a well-ventilated area to prevent its vapor concentration from exceeding safety standards. When using and storing the compound, it should be handled in accordance with relevant regulations and safe operating procedures.
Application
1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid (7-azaindole-3-carboxylic acid, CAS 156270-06-3) is a versatile heterocyclic building block widely used in medicinal chemistry and drug discovery. Its 7-azaindole core serves as a purine bioisostere, providing dual hydrogen-bonding motifs that enhance target binding affinity. The carboxylic acid at the 3-position enables facile amide and ester formation, allowing rapid derivatization for structure-activity relationship (SAR) studies. This scaffold is a key intermediate for the synthesis of potent kinase inhibitors targeting cancer, inflammation, and autoimmune diseases, including FGFR, PI3K, CDK, and EGFR inhibitors. It is also employed in the development of antiviral, antibacterial, and antifungal agents. Its rigid, electron-rich azaindole ring improves metabolic stability and pharmacokinetic properties. Additionally, this intermediate supports agrochemical research (herbicides, fungicides) and the preparation of functional materials. High purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
