4-Hydroxymethyl-7-azaindole(CAS#936549-95-0)

Introduction

It is an organic compound with a molecular formula of C9H8N2O and a molecular weight of 160.17g/mol. It has the following properties:

1. Appearance and properties: It is a white or off-white solid with a special fragrance.

2. Melting Point: its melting point is about 182-185 ° C.

3. Solubility: It has low solubility in water, but better solubility in organic solvents such as ethanol, dimethyl sulfoxide and dichloromethane.

It can be used as a catalyst and intermediate in organic synthesis. It also has certain applications in drug research and manufacturing, including synthetic drugs, antibiotics and antibacterial agents. In addition, it can also be used as probes and markers in research biology.

The preparation method of the compound can be synthesized by hetero-chelation reaction using pyrrole and formaldehyde as raw materials. Specific synthetic routes and reaction conditions can be adjusted according to specific needs and relevant literature.

Regarding safety information, due to the characteristics of compounds and the general properties of organic compounds, the following should be noted when using:

1. It may decompose at high temperatures to produce toxic gases, so you need to pay attention to a well-ventilated environment during handling and storage.

2. It is irritating to the eyes and skin, so be sure to wear appropriate personal protective equipment when exposed to this compound.

3. Avoid inhalation or intake during use to prevent damage to health.

4. After using and treating the compound, properly dispose of the waste and dispose of it in accordance with local environmental regulations.

Application
4-Hydroxymethyl-7-azaindole (7-Azaindole-4-methanol) is a functionalized heterocyclic building block based on a dual hydrogen-bonding 7-azaindole hinge-binding motif, a privileged scaffold in kinase inhibitor design. This compound targets Tyrosine Protein Kinase SRC and DDX3 helicase via the purine binding site, showing antiproliferative activity against cancer cells such as HeLa and MCF-7. It serves as a key pharmaceutical intermediate for developing targeted covalent inhibitors, including FGFR inhibitors, enabling efficient cross-coupling (Suzuki-Miyaura, Buchwald-Hartwig) and functional group transformations (oxidation, amidation, Mitsunobu). The compound supports structure-activity relationship (SAR) studies in oncology, antiviral, and antibacterial drug discovery, as well as CNS agent development, allowing flexible R&D to GMP scale-up. Xinchem offers reliable custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity this essential building block with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and global supply.