Indazole(CAS#271-44-3)

Introduction

Indazole is a nitrogen-containing aromatic compound with the chemical formula C7H6N2. It is a white crystalline solid, soluble in alcohols and ketone solvents, slightly soluble in water. Indazole has low toxicity.Indazole has a wide range of applications. In addition, indazole is used as an additive for dyes, coatings, plastics, and rubber, as well as as a photochemical catalyst, among others.There are several ways to prepare indazole. The most common method is to react pyrazole with formaldehyde at high temperature through pyrazole thermal synthesis. Indazole can also be synthesized by methods such as amination reaction and debromination of brominated indazole.Regarding the safety of indazole, it is a low-toxicity compound, but it still needs to be handled with caution. Exposure to indazole may cause eye and skin irritation, so appropriate personal protective equipment should be worn during exposure. A well-ventilated environment should be used in the laboratory and the inhalation of its dust should be avoided. When indazole is ingested in large amounts, it may have effects on the central nervous system and should be avoided.
Application
Indazole is a privileged nitrogen-containing heterocyclic scaffold widely used in medicinal chemistry and drug discovery. Its bicyclic structure, composed of a pyrazole ring fused to a benzene ring, serves as a bioisostere for indole, benzimidazole, and purine, offering unique hydrogen bonding capabilities and metabolic stability. Indazole derivatives exhibit a broad spectrum of biological activities, including potent anticancer effects as kinase inhibitors (e.g., FGFR, PI3K, CDK, and PARP inhibitors), anti-inflammatory, antiviral, antibacterial, and antifungal properties. This versatile building block is a key intermediate in the synthesis of FDA-approved drugs such as pazopanib (VEGFR inhibitor), axitinib, and nilotinib, as well as clinical candidates for neurological disorders. In agrochemical research, indazole-based compounds are developed as herbicides and fungicides. Indazole also serves as a valuable ligand in coordination chemistry and as a precursor for functional materials. High-purity indazole ensures reproducible results in high-throughput screening, structure-activity relationship (SAR) studies, and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of indazole with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.