6-(1H)INDAZOLE CARBOXYLIC ACID METHYL ESTER(CAS#170487-40-8)
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Introduction
Methyl 1H-indazole-6-carboxylic acid is an organic compound. It is a white crystalline solid with a strong pungent odor.In terms of use, methyl 1H-indazole-6-carboxylic acid can be used as a chemical reagent for carboxylic acid activation and acylation in organic synthesis reactions. It can be used as an esterifying agent to react with carboxylic acids to produce corresponding esterification products.In terms of synthesis method, methyl 1H-indazole-6-carboxylic acid can be obtained by the reaction of indazole and chloroformic acid. Using indazole as raw material, it is reacted in an alcohol solvent, chloroformic acid is added, and the target product can be obtained by esterification reaction.It is irritating and may have an irritating effect on the eyes and skin, so wear protective glasses and gloves during operation. When storing, it should be sealed and kept away from fire and oxidants.
Application
Methyl 1H-indazole-6-carboxylate (CAS 170487-40-8) is a key heterocyclic building block for pharmaceutical R&D, organic synthesis, and agrochemical discovery. As a privileged indazole scaffold with a methyl ester at the 6-position, it serves as a critical pharmaceutical intermediate for synthesizing anti-inflammatory, analgesic, anti-cancer, and anti-microbial agents. Research has shown indazole compounds target TTK kinase for cancer therapy, and this derivative is employed in medicinal chemistry for creating libraries for kinase inhibitors (e.g., FGFR, PI3K, CDK), as well as antiviral and antibacterial candidates. The ester group provides a versatile handle for amidation, hydrolysis, or reduction, supporting rapid structure-activity relationship (SAR) studies and high-throughput screening. In agricultural chemistry, it contributes to formulating effective pesticides and herbicides for crop protection. Additionally, it is explored for material science and as a reference standard for analytical methods. Xinchem offers reliable custom synthesis, custom chemical synthesis, and contract manufacturing for this high-purity building block with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and global supply.
