1H-Indazole,5-broMo-4-fluoro(CAS#1082041-85-7)

Introduction

The following is an introduction to its nature, use, preparation method and safety information:Quality:- Appearance: 4-Fluoro-5-bromo-indazole is usually a white crystalline or yellowish solid.- Solubility: 4-fluoro-5-bromo-indazole has good solubility in some organic solvents.Use:- Chemical reagents: 4-fluoro-5-bromo-indazole can be used as a reagent in organic synthesis reactions.- Other applications: Due to its unique structure, other potential applications are being studied.Method:4-Fluoro-5-bromo-indazole can be prepared by organic synthesis methods, and a common preparation method is a substitution reaction through the hydrogen bonding site of indazole.Safety Information:The specific application of 4-fluoro-5-bromo-indazole is still being studied, and there is no specific safety information and risk assessment data for it. When handling any organic compounds, care should be taken to follow safe laboratory operating procedures and wear appropriate personal protective equipment such as lab gloves and goggles. When handling and storing, contact with oxidants and flammables should be avoided. If necessary, assessments and safety measures should be taken based on further scientific research and experimental data.

Application
5-Bromo-4-fluoro-1H-indazole (CAS 1082041-85-7) is a multifunctional heterocyclic building block featuring a bromine at the 5-position and a fluorine at the 4-position on the indazole core. The indazole ring is a privileged scaffold in medicinal chemistry, serving as a bioisostere for indole and purine. The bromine enables efficient palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) for introducing diverse aryl or alkyl groups, while the fluorine enhances metabolic stability, lipophilicity, and target binding affinity. This compound is a key intermediate for the synthesis of potent kinase inhibitors targeting cancer, inflammation, and autoimmune diseases, including FGFR, PI3K, CDK, and PARP inhibitors. It is also employed in the development of antiviral, antibacterial, and antifungal agents. Its rigid, electron-rich indazole core provides excellent target engagement and pharmacokinetic properties, facilitating rapid structure-activity relationship (SAR) studies. High purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.