1H-Indazole-7-carbonitrile(CAS#256228-64-5)

Introduction

1H-Indazole-7-carcoalonitrile is an organic compound. It is a white solid, odorless, and poorly soluble in water. It has a special molecular structure that allows it to be used to synthesize other organic compounds.1H-Indazole-7-carnitrile has a wide range of applications in organic synthesis. It can also be used in the preparation and synthesis of important indole compounds, such as indoles and indolesine.The method of preparing 1H-indazole-7-carnitrile can be carried out by different pathways. A common method is to react indazole with hydrocyanic acid and then react under alkaline conditions to synthesize 1H-indazole-7-formonitrile.Safety information: 1H-indazole-7-carbonitrile is relatively stable under normal conditions. Safety measures are still required when handling and using. Avoid contact with skin and eyes, and wear appropriate personal protective equipment such as gloves and goggles if necessary. It is to be stored in an airtight container, away from fire and oxidants. If you accidentally come into contact with it or cause physical discomfort, please seek medical attention promptly.

Application
1H-Indazole-7-carbonitrile (CAS 256228-64-5) is a privileged heterocyclic building block and key pharmaceutical intermediate widely utilized in medicinal chemistry. Its unique indazole core with a nitrile group at the 7-position serves as a versatile scaffold for drug discovery, particularly for the synthesis of selective neuronal nitric oxide synthase (nNOS) inhibitors, kinase inhibitors, and JAK inhibitors. Research trends increasingly focus on its application in developing potent anticancer agents for renal cell carcinoma, leukemia, and solid tumors, as well as antiviral (HIV-1 reverse transcriptase) and anti-inflammatory therapeutics. The nitrile group provides a valuable handle for further functionalization via cross-coupling and cycloaddition reactions. Its derivatives also show potential in treating chemotherapy-induced nausea and metabolic disorders. High purity ensures reproducible results in high-throughput screening and SAR studies. Xinchem offers reliable custom synthesis, custom chemical synthesis, and contract manufacturing of this essential indazole building block with flexible scaling from R&D to commercial tons. Contact us for a competitive quote.