2-Hydroxy-5-methylpyridine(CAS#1003-68-5)
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes R36/37/39 - |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37 - Wear suitable gloves. |
| WGK Germany | 3 |
| HS Code | 29333990 |
Introduction
2-Hydroxy-5-methylpyridine. It has the following properties:Appearance: Colorless liquid.Solubility: Soluble in water and most organic solvents.Density: approx. 1.06 g/cm³.2-Hydroxy-5-methylpyridine can be used for the following:As a common reagent, it is used as a catalyst and solvent in organic synthesis reactions.It can also be used as a complexing agent for metal ions, for coordination chemistry and catalytic reactions.The method for preparing 2-hydroxy-5-methylpyridine includes the following steps:Ethyl acetate is reacted with pyrrole to form acetylpyrrole.Acetylpyrrole is condensed with formaldehyde under alkaline conditions to form 2-hydroxy-5-methylpyridine.Safety Information:2-Hydroxy-5-methylpyridine should be stored in a dry, ventilated place, away from ignition and oxidants.Wear appropriate personal protective equipment such as protective eyewear and gloves when using and handling.Avoid inhalation, ingestion, or contact with skin.Pay attention to the safe operation practices of the laboratory during use to avoid the release of harmful gases or substances.In case of contact or inhalation, wash the affected area immediately and, if necessary, seek medical advice.
Application
2-Hydroxy-5-methylpyridine (5-methylpyridin-2-ol, CAS 1003-68-5) is a versatile heterocyclic building block widely used in pharmaceutical and agrochemical research. Its pyridone core with a methyl substituent enables diverse functionalization via N-alkylation, O-alkylation, and cross-coupling reactions. This compound serves as a key intermediate for the synthesis of bioactive molecules including kinase inhibitors (e.g., JAK, BTK, CDK), antiviral agents, and antibacterial drugs. It is also employed in the preparation of pyridine-based ligands for catalysis and metal-organic frameworks (MOFs). In agrochemistry, derivatives are used to develop herbicides and fungicides with improved crop protection profiles. Its unique tautomeric equilibrium between the pyridone and hydroxypyridine forms provides versatile reactivity and hydrogen-bonding capability, enhancing target binding affinity. High purity ensures reproducible results in high-throughput screening, SAR studies, and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 2-hydroxy-5-methylpyridine with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
