6-Bromo-5-chloro-2-pyridinamine(CAS#1004294-58-9)

Introduction

6-Bromo-5-chloro-2-pyridine is an organic compound. The following is an introduction to its nature, use, preparation and safety information:Quality:- Appearance: 6-Bromo-5-chloro-2-pyridine is a colorless to pale yellow crystal.- Solubility: It is insoluble in water, but soluble in organic solvents such as ethanol, methylene chloride, etc.Use:- Insecticides: It can also be used as a raw material for pesticides in agriculture and horticulture.- Research use: Due to its chemical reactivity activity, it is also widely used in chemical research.Method:The preparation method of 6-bromo-5-chloro-2-pyridine is usually achieved by adding bromine and chlorine to pyridine under appropriate conditions.Safety Information:The relevant safety information of 6-bromo-5-chloro-2-pyridine does not provide sufficient data and should be handled and used with caution. As a chemical, it can be potentially harmful to the human body. Proper laboratory operating procedures should be followed, appropriate protective equipment should be worn, and handling and storage should be carried out in strict accordance with relevant regulations. If necessary, it should be performed in a suitable laboratory environment and in accordance with relevant safety guidelines and regulations.

Application
6-Bromo-5-chloro-2-pyridinamine is a multifunctional halogenated heterocyclic building block used extensively in medicinal chemistry and drug discovery. The ortho-dihalo substitution pattern enables selective cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) at either the bromine or chlorine site, allowing rapid construction of diverse 2-aminopyridine-based libraries. This scaffold is a key intermediate for synthesizing potent kinase inhibitors targeting cancer, inflammation, and autoimmune diseases (e.g., JAK, BTK, CDK inhibitors), as well as antiviral, antibacterial, and antifungal agents. The free amino group permits acylation, alkylation, or urea formation, while the rigid, electron-deficient pyridine core enhances target binding affinity and metabolic stability. High purity ensures reproducible results in high-throughput screening and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.