2-Cyano-5-nitropyridine(CAS#100367-55-3)
Introduction
2-Cyano-5-nitropyridine, also known as DNT (Dinitrotoluenes), is an organic compound. The following is an introduction to its properties, uses, manufacturing methods and safety information:Quality:- Appearance: 2-Cyano-5-nitropyridine is a white crystalline solid.- Solubility: Good solubility among common organic solvents.Use:- Explosives: 2-cyano-5-nitropyridine is a commonly used explosive ingredient. It has high explosive performance and stability, and is often used in the preparation of explosives and bombs.- Organic synthesis: It can also be used as an intermediate in organic synthesis for the preparation of other organic compounds.Method:- 2-Cyano-5-nitropyridine can be synthesized by nitrification. Nitrication is the reaction of nitric acid with organic compounds to introduce a nitro group. The specific preparation method varies slightly depending on the specific conditions.Safety Information:- 2-Cyano-5-nitropyridine is an explosive compound that is potentially hazardous. Necessary safety measures should be taken during handling to avoid direct contact, inhalation or accidental ingestion.- The nitrification process needs to be carried out under controlled conditions to ensure safety. Appropriate protective equipment and operating procedures should be used.- When storing and handling, avoid contact with flammable substances, strong oxidizing agents, and other substances to prevent accidents.- Waste should be disposed of in accordance with relevant laws and regulations, and should not be inverted or discharged.
Application
2-Cyano-5-nitropyridine (CAS 100367-55-3) is a high-purity, electron-deficient heterocyclic building block widely used in medicinal chemistry and pharmaceutical R&D. The presence of both a strong electron-withdrawing nitro group and a reactive cyano group on the pyridine ring enables nucleophilic aromatic substitution and cross-coupling reactions, facilitating the construction of diverse drug-like scaffolds. It serves as a key intermediate for the synthesis of kinase inhibitors (e.g., JAK, BTK, CDK), antiviral agents, and antibacterial compounds. The nitro group can be reduced to an amino group for further derivatization, while the cyano allows transformation to amides, amidines, or tetrazoles. This scaffold is also employed in agrochemical development (herbicides, fungicides) and in the preparation of functional materials such as organic semiconductors. Its rigid, electron-deficient core enhances metabolic stability and target binding affinity. High purity ensures reproducible results in high-throughput screening and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
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