1-(chloromethyl)-2,3-difluorobenzene(CAS#446-57-1)
Introduction
1-(chloromethyl)-2,3-difluorobenzene, chemical formula C7H5ClF2, is an organic compound. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: 1-(chloromethyl)-2,3-difluorobenzene is a colorless liquid.
-Solubility: It is soluble in many organic solvents, such as alcohols and ethers.
-Boiling point: Its boiling point is about 165-167°C.
-Density: Its density is about 1.29g/cm³.
Use:
- 1-(chloromethyl)-2,3-difluorobenzene is widely used in the field of organic synthesis. It is an important chemical intermediate that can be used in the synthesis of other compounds.
Preparation Method:
- 1-(chloromethyl)-2,3-difluorobenzene is usually obtained by reacting methyl chloride with 2,3-difluorobenzene. The specific synthesis steps are as follows:
1. Chloromethane reacts with 2,3-difluorobenzene to generate 1-(chloromethyl)-2,3-difluorobenzene.
Safety Information:
- 1-(chloromethyl)-2,3-difluorobenzene requires careful use and handling. It is a hazardous substance that may cause harm to human health and the environment.
-Use should follow appropriate protective measures, such as wearing chemical protective gloves and goggles.
-Avoid contact with skin, eyes and inhalation of vapors during storage and handling.
-If ingested or inhaled, seek medical attention immediately.
Application
1-(Chloromethyl)-2,3-difluorobenzene (2,3-difluorobenzyl chloride, CAS 446-57-1) is a reactive fluorinated benzyl halide serving as a key pharmaceutical intermediate and versatile building block. Its chloromethyl group enables efficient nucleophilic substitution with amines, thiols, and alcohols to introduce the 2,3-difluorobenzyl moiety into drug candidates. The two fluorine atoms enhance metabolic stability, lipophilicity, and target binding affinity. This compound is widely used in the synthesis of fluoroquinolone antibiotics, antiviral agents, and central nervous system (CNS) drugs including antidepressants and antipsychotics. In agrochemical research, it serves as a precursor for selective herbicides, fungicides, and insecticides with improved efficacy and environmental safety. It also participates in palladium-catalyzed cross-couplings and can be oxidized to the corresponding aldehyde or carboxylic acid. Additional applications include specialty polymers, liquid crystal materials, and fluorescent probes. High purity ensures reproducible results in SAR studies, high‑throughput screening, and GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.
