![2,9-diazabicyclo[4.3.0]nona-2,4,7,10-tetraene-7-carbaldehyde)(CAS#4649-09-6) Featured Image](https://www.xinchem.com/uploads/tetraene.png)
2,9-diazabicyclo[4.3.0]nona-2,4,7,10-tetraene-7-carbaldehyde)(CAS#4649-09-6)
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R43 - May cause sensitization by skin contact |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. |
| WGK Germany | 3 |
| HS Code | 29349990 |
| Hazard Class | IRRITANT |
Brief introduction
7-azaindole-3-carboxaldehyde is an organic compound. The following is an introduction to its properties, uses, manufacturing methods and safety information:
Quality:
- Appearance: 7-azaindole-3-carboxaldehyde is a light yellow crystalline solid.
- Solubility: It is soluble in some organic solvents, such as ethanol and ether, but slightly soluble in water.
Use:
- Chemical synthesis: 7-azaindole-3-carboxaldehyde is a difunctional compound that can be used as an intermediate in the synthesis of other compounds.
Method:
There are several ways to prepare 7-azaindole-3-carboxaldehyde, and the following is a simplified method:
3-aminoindole is reacted with formaldehyde under appropriate reaction conditions to generate 7-azaindole-3-carboxaldehyde.
Safety Information:
- 7-azaindole-3-carboxaldehyde is an organic compound that should be avoided from contact with the skin and inhaled.
- When using, take appropriate precautions, such as wearing protective gloves, glasses, and lab coats.
Application
1H-Pyrrolo[2,3-b]pyridine-5-carbaldehyde (7-Azaindole-5-carboxaldehyde, CAS 849067-90-9) is a functionalized heterocyclic building block featuring a reactive aldehyde group. Its 7-azaindole core is a privileged purine bioisostere in drug discovery, and the formyl handle enables reductive amination, condensation, Wittig olefination, and cross-coupling reactions for rapid SAR exploration. This scaffold is extensively used to develop potent inhibitors of fibroblast growth factor receptors (FGFR) for targeted cancer therapy and has demonstrated nanomolar activity as a human neutrophil elastase (HNE) inhibitor for respiratory inflammatory diseases. Its derivatives also show promise as JAK, BTK, and CDK inhibitors, as well as carbonic anhydrase VII and cytochrome b inhibitors for antimalarial research. In targeted protein degradation (PROTAC), the aldehyde serves as a conjugation point for linker attachment. Additional applications include agrochemical discovery, fluorescent probe synthesis, and functional materials. High purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
