Methyl 2-Bromo-5-Chloro-1,3-Thiazole-4-Carboxylate(CAS#1053655-63-2)

Introduction

Methyl 2-bromo-5-chlorothiazole-4-carboxylic acid is an organic compound.Quality:Methyl 2-bromo-5-chlorothiazole-4-carboxylic acid is a colorless to pale yellow liquid. It is insoluble in water at room temperature but can be soluble in organic solvents such as ether and methanol.Use:Methyl 2-bromo-5-chlorothiazole-4-carboxylic acid has a wide range of applications in organic synthesis.Method:The synthesis methods of methyl 2-bromo-5-chlorothiazole-4-carboxylic acid are relatively diverse, and the common method is to react thiazole with sodium bromate and cuprous chloride, and then react with methanol to obtain the target product.Safety Information: It is an organic compound that may be irritating and toxic and may be harmful to the environment. Protective gloves, glasses and protective clothing should be worn during operation to avoid direct contact. It should be operated in a well-ventilated environment and stored properly to avoid contact with oxidants or combustibles. If necessary, the compound's safety data sheet should be read or a professional should be consulted.

Application
Methyl 2-Bromo-5-Chloro-1,3-Thiazole-4-Carboxylate is a multifunctional heterocyclic building block for pharmaceutical and agrochemical R&D. The reactive bromine and chlorine atoms enable sequential, orthogonal cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) and nucleophilic aromatic substitution, allowing rapid construction of diverse 2,4,5-trisubstituted thiazole libraries. This scaffold is a key intermediate for potent kinase inhibitors targeting cancer, inflammation, and autoimmune diseases (e.g., PI3K, CDK, BTK, EGFR). The methyl ester provides a handle for hydrolysis or amidation, facilitating structure-activity relationship (SAR) studies. Derivatives show promising antibacterial, antifungal, antiviral, and anti-inflammatory activities. It also serves as a precursor for agrochemicals (herbicides, fungicides) and functional materials. High purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.