4-Fluoronitrobenzene(CAS#350-46-9)

Introduction

4-Fluoronitrobenzene is an organic compound. The following is an introduction to the properties, uses, preparation methods and safety information of 4-fluoronitrobenzene:Quality:- Appearance: Colorless crystals- Solubility: Soluble in organic solvents such as ethanol, ether and chloroform- Stability: Stable at room temperature, not easy to decompose- Flammability: flammable, with explosion hazard in case of open flameUse:- Pesticide manufacturing: 4-fluoronitrobenzene is an important intermediate that can be used in the synthesis of agricultural chemicals such as pesticides and insecticides.- Dye manufacturing: 4-fluoronitrobenzene can be used in the synthesis of dyes to give the dye specific chemical properties.Method:- Starting with benzene, 4-fluoronitrobenzene is synthesized through a series of chemical reactions. Specific methods include fluorination, nitrification, and reduction.Safety Information:- 4-Fluoronitrobenzene is a flammable compound and should be avoided from contact with open flames or high temperatures.- When operating, take appropriate precautions, such as wearing protective gloves, goggles, and protective clothing.- During storage, keep 4-fluoronitrobenzene away from heat and ignition sources and keep the container tightly sealed.

Application

4-Fluoronitrobenzene (1-Fluoro-4-nitrobenzene, CAS 350-46-9) is a high-purity aryl fluorinated building block widely used as a key pharmaceutical intermediate, agrochemical intermediate, and specialty chemical reagent. As a premium pharmaceutical intermediate, it serves as a critical precursor in the synthesis of fluoroquinolone antibiotics, including norfloxacin and ciprofloxacin derivatives, as well as in the development of kinase inhibitors for targeted cancer therapies and central nervous system (CNS) drugs such as antipsychotics and antidepressants. In the agrochemical industry, this versatile building block acts as a key precursor for fluorinated herbicides, pesticides, and fungicides, where the electron-withdrawing fluorine and nitro groups improve bioavailability and environmental stability. It is also employed in the production of azo dyes, fluorescent markers, and novel soluble aromatic polyimides such as 1,3,5-tris(4-aminophenoxy)benzene. The activated para-fluorine undergoes selective nucleophilic aromatic substitution (SNAr) with amines, alkoxides, and thiols, as well as Suzuki-Miyaura and Ullmann cross-coupling reactions, enabling efficient construction of complex organic molecules for medicinal chemistry and materials science. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 4-fluoronitrobenzene with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.