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methyl 5-aminopyrazine-2-carboxylate(CAS#13924-94-2)

Chemical Property:

Molecular Formula C6H7N3O2
Molar Mass 153.14
Density 1.319
Melting Point 230-232?C
Boling Point 363℃
Flash Point 173℃
Vapor Presure 0mmHg at 25°C
Storage Condition Keep in dark place,Sealed in dry,2-8°C
Refractive Index 1.577

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Introduction

Methyl 5-aminopyrazine-2-carboxylate, also known as methyl-2-amino-5-pyrazine methyl ester, is an organic compound. The following is an introduction to its properties, uses, manufacturing methods and safety information:Quality:- Appearance: Methyl 5-aminopyrazine-2-carboxylate is a white crystalline solid.- Solubility: slightly soluble in water, soluble in organic solvents such as alcohols and ethers.Use:Methyl 5-aminopyrazine-2-carboxylate has a variety of uses in organic synthesis, such as:- as an intermediate in organic synthesis for the preparation of other compounds;- can be used in the synthesis of benzothiophenes and benzothiazine compounds, which have antibacterial and antioxidant properties;Method:Methyl 5-aminopyrazine-2-carboxylate can be prepared by the following reactions:Condensation reaction between methyl-2-amino-5-pyrazinone and methyl formate.The specific steps are as follows:- dissolve methyl-2-amino-5-pyrazinone in dichloromethane;- Slowly add methyl formate and catalyst (usually acid catalyst);- Appropriate temperature and reaction time, which usually requires heating;- Once the reaction is complete, the solid product is filtered and purified.Safety Information:- Methyl 5-aminopyrazine-2-carboxylate is non-toxic to humans under normal conditions and is non-corrosive.- It is a chemical substance and general laboratory safety operating procedures should be followed, such as wearing appropriate protective equipment (such as gloves and goggles).- Do not expose it to combustibles or oxidizing agents and keep it away from fire.

Application
Methyl 5-aminopyrazine-2-carboxylate (CAS 13924-94-2) is a versatile heterocyclic building block featuring a primary amine at the 5-position and a methyl ester at the 2-position. It is a key intermediate in medicinal chemistry for the synthesis of bioactive molecules, including antituberculosis drugs (e.g., pyrazinamide analogs), kinase inhibitors, antiviral agents, and antibacterial compounds. The amino group enables amide coupling, urea formation, and heterocycle construction, while the methyl ester allows hydrolysis to the corresponding carboxylic acid for further derivatization. This scaffold is also employed in agrochemical research for herbicide and fungicide development. Its pyrazine core provides excellent metabolic stability and target binding affinity. High purity ensures reproducible results in high-throughput screening and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.


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