2,3-PYRAZINEDIAMINE(CAS#13134-31-1)

Introduction

2,3-Diaminopiperazine is an organic compound with the chemical formula C6H9N3. It is a white crystalline solid, soluble in water and organic solvents.

2,3-diaminopiperazine is widely used in agriculture and medicine. It is used as an intermediate for insecticides and can be used to control a variety of insects and pests. In addition, it is also used as a raw material for the synthesis of some drugs, and has the functions of antibacterial, antiviral and lowering blood pressure.

2,3-Diaminopiperazine can be prepared by a two-step reaction. First, a 2,3-dihalopiperazine (e. g., 2,3-dibromo-piperazine) is taken as a starting material and then reacted with ammonia to give 2,3-diaminopiperazine. This process requires the use of suitable solvents and catalysts, as well as appropriate temperature and time control.

Regarding the safety information of 2,3-diaminopiperazine, it is a toxic substance that may cause irritation to the human body when exposed. When using or preparing 2,3-diaminopiperazine, appropriate protective measures should be taken, such as wearing protective gloves, goggles and protective face masks. At the same time, when storing and handling the compound, care should be taken to avoid contact with strong oxidants and combustibles to avoid fire or explosion. In the course of use if accidentally inhaled or in contact with the skin, eyes or into, should immediately rinse with plenty of water and seek medical help.

Application
2,3-Pyrazinediamine (CAS 13134-31-1, also known as 2,3-Diaminopyrazine) is a heterocyclic diamine used as a key pharmaceutical building block and organic intermediate. In drug discovery, this heterocyclic diamine serves as a privileged scaffold for synthesizing kinase inhibitors and anticancer agents, with derivatives showing cytotoxic activity against human colon cancer (HCT‑116) and leukemia (K562, HL-60) cell lines. The compound acts as a quaternary ammonium blocker of presynaptic potassium channels, prolonging action potentials and enhancing acetylcholine release, with clinical potential in neuromuscular disorders such as Lambert‑Eaton myasthenic syndrome (LEMS). In coordination chemistry, it functions as a bidentate ligand, forming metal complexes and Schiff-base ligands for catalysis and materials science. It is also used in synthesizing cross-linked polymers for selective mercury(II) removal from wastewater. Additionally, derivatives exhibit antibacterial, antiviral and antihypertensive activities, making this organic intermediate valuable for agrochemical synthesis including insecticides. Xinchem offers custom synthesis, custom chemical synthesis and contract manufacturing of 2,3-pyrazinediamine with flexible scaling from R&D to commercial tons. Contact us for a competitive quote.