METHYL 4-BROMO-3-METHYLBENZOATE(CAS#148547-19-7)
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29163990 |
| Hazard Note | Irritant |
Introduction
METHYL 4-BROMO-3-METHYLBENZOATE, also known as METHYL p-bromobenzoate, is an organic compound. The following is a description of its nature, use, formulation and safety information:
Nature:
1. Appearance: colorless to light yellow liquid.
2. Molecular formula: C9H9BrO2.
3. Molecular weight: 227.07g/mol.
4. Solubility: Soluble in organic solvents, such as ethanol, dichloromethane and ether.
Use:
1. METHYL 4-BROMO-3-METHYLBENZOATE can be used as a fragrance chemical for the food and perfume industries.
2. It is also used as substrates and intermediates in organic synthesis reactions.
Method:
1. METHYL 4-BROMO-3-METHYLBENZOATE can be obtained by reacting 3-METHYL -4-bromobenzoic acid with methanol under acidic conditions.
2. Under the reaction conditions, a longer reaction time is required, and heating and stirring are generally required.
Safety Information:
1. METHYL 4-BROMO-3-METHYLBENZOATE is irritating and corrosive, and can cause irritation and burns in contact with skin and eyes.
2. During operation, wear protective gloves and goggles and ensure that the operation is carried out in a well-ventilated place.
3. In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical help.
4. Avoid contact with strong oxidants or strong acids to avoid dangerous reactions.
5. When storing, it should be stored in a sealed container, away from fire and high temperature.
Application
Methyl 4-bromo-3-methylbenzoate (CAS 148547-19-7) is a functionalized benzoic ester widely used as a versatile building block in medicinal chemistry and organic synthesis. The bromine at the 4-position enables efficient palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) to rapidly introduce diverse aryl, heteroaryl, or alkyl groups, while the methyl ester provides a handle for hydrolysis to the carboxylic acid or reduction to the alcohol, facilitating further derivatization. The methyl group at the 3-position offers steric and electronic modulation. This intermediate is a key precursor for the synthesis of biaryl-containing drug candidates, including kinase inhibitors (e.g., BTK, EGFR, and CDK inhibitors), antihypertensives, and anti-inflammatory agents. In agrochemical research, it is used to prepare herbicides and fungicides with enhanced crop protection profiles. Additionally, this scaffold supports the development of functional polymers, organic electronics, and fluorescent probes. High purity ensures reproducible results in high-throughput screening, SAR studies, and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
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