5-Bromo-1H-pyrazolo[3,4-b]pyridin-3-amine(CAS#405224-24-0)

Introduction

3-Amino-5-bromo-1H-pyrazolo[3,4-B]pyridine is a functional compound with a variety of properties and applications.**Quality**:- Appearance: 3-Amino-5-bromo-1H-pyrazolo[3,4-B]pyridine is a white or light yellow crystalline solid.- Chemical structure: It contains a pyrazole ring and a pyridine ring where carbon atom 1 on the pyrazole ring is attached to carbon atom 3 on the pyridine ring.- Solubility: 3-amino-5-bromo-1H-pyrazole[3,4-B]pyridine is soluble in organic solvents such as alcohols, ethers, and chlorinated hydrocarbons, but insoluble in water.**Apply**:- As a dye: It can be used in the dye industry to dye materials such as fibers, plastics, and coatings.- As a photosensitizer: It can also be used as a photosensitizer in the optoelectronics industry such as lithography.**Method**:There are many preparation methods for 3-amino-5-bromo-1H-pyrazolo[3,4-B]pyridine, and one of the common methods is to cyclize 3-amino-5-bromo-1H-pyrazole and 1,2-dichlorobenzene in the presence of copper iodide.**Safety Information**:- Pay attention to personal protective measures and wear appropriate protective glasses and gloves before use.- Avoid inhaling dust, fumes, or vapors from the compound.- Avoid contact with skin and eyes, rinse immediately with plenty of water and seek medical attention.- Keep storage containers tightly closed and store in a cool, dry place away from fire and oxidants.

Application
5-Bromo-1H-pyrazolo[3,4-b]pyridin-3-amine (CAS 405224-24-0) is a multifunctional heterocyclic building block widely used in medicinal chemistry and drug discovery. Its fused pyrazolo[3,4-b]pyridine core with a bromine at position 5 and an amino group at position 3 provides three distinct synthetic handles for diversification. The amino group allows amide formation, urea coupling, or heterocycle annulation, while the bromine enables cross-coupling reactions (Suzuki, Buchwald-Hartwig, Sonogashira, Ullmann) for introducing aryl, heteroaryl, or alkyl groups. This compound serves as a key intermediate for the development of potent kinase inhibitors targeting various families (JAK, BTK, CDK, TBK1, PI3K) for treating cancers, inflammation, autoimmune disorders, and infectious diseases. It also finds applications in agrochemical research and as a scaffold for generating focused compound libraries in high-throughput screening. Its high purity and reliable quality ensure reproducibility in complex synthetic routes. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this key intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.