BOC-D-ALA-OME（CAS# 91103-47-8)
| WGK Germany | 3 |
Introduction
boc-d-ala-ome(boc-d-ala-ome) is a chemical substance, its properties, use, preparation and safety information are as follows:
Nature:
-Appearance: White or off-white solid
-Molecular formula: C13H23NO5
-Molecular weight: 281.33g/mol
-melting point: about 50-52 ℃
-Solubility: Soluble in some organic solvents, such as methanol, acetone and dichloromethane
Use:
boc-d-ala-ome are mainly used for peptide synthesis reactions in organic synthesis. As a protecting group, it can protect the hydroxyl function of alanine to prevent unnecessary reactions during the reaction. Various polypeptide compounds or drugs can be synthesized using boc-d-ala-ome.
Method:
The preparation of boc-d-ala-ome is usually obtained by reacting boc-alanine with methanol. The specific preparation method can be carried out in a chemical laboratory.
Safety Information:
- boc-d-ala-ome are generally non-hazardous under normal operating conditions. However, as with any chemical, appropriate laboratory safety practices should be followed.
-Wear suitable protective goggles, gloves and laboratory coats for safety during use, storage or handling.
-Avoid inhaling dust, avoid skin contact and throat contact.
-When using and handling the compound, it should be operated in a well-ventilated place to avoid excessive vapor concentration
-If any dangerous situation occurs during accidental purification, melting point determination or other experiments, appropriate emergency measures should be taken immediately and professional consultation should be consulted.
Application
Boc-D-Ala-OMe (N-(tert-Butoxycarbonyl)-D-alanine methyl ester, CAS 91103-47-8) is a chirally pure, orthogonally protected D-amino acid derivative. It serves as a critical building block for introducing D‑alanine residues with defined stereochemistry into peptides, peptidomimetics, and chiral small molecules. In peptide synthesis, the Boc (tert‑butyloxycarbonyl) group protects the amine during chain assembly and is removed under mild acidic conditions, while the methyl ester enhances solubility in organic solvents. This compound is the D‑enantiomer of Boc‑L‑Ala‑OMe, enabling the construction of stereodefined peptides such as t‑Boc‑(L‑Ala‑D‑Ala)₄‑OMe. In drug development, incorporating D‑alanine enhances peptide stability against enzymatic degradation, improving pharmacokinetic and pharmacodynamic properties. It is also employed in enzyme inhibition studies, proteomics, and as a substrate in biocatalytic resolution. Xinchem offers flexible custom synthesis and contract manufacturing of high‑purity Boc‑D‑Ala‑OMe, supporting reliable scaling from R&D to commercial volumes. Contact us for a competitive quote and global supply.
