EDC (N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide HCl)(CAS#25952-53-8)
| Risk Codes | R34 – Causes burns R36/37/38 – Irritating to eyes, respiratory system and skin. R41 – Risk of serious damage to eyes R37/38 – Irritating to respiratory system and skin. R20/21/22 – Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S37/39 – Wear suitable gloves and eye/face protection S36 – Wear suitable protective clothing. |
| UN IDs | UN 2735 8/PG 3 |
| WGK Germany | 3 |
| RTECS | FF2200000 |
| FLUKA BRAND F CODES | 1-3-10 |
| TSCA | Y |
| HS Code | 29252000 |
| Hazard Note | Irritant |
| Toxicity | LD50 intravenous in mouse: 56mg/kg |
Introduction
1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride, also known as EDC hydrochloride. The following is an introduction to its properties, uses, preparation methods, and safety information:Quality:1. EDC hydrochloride is a white crystalline powder with weak acidity.2. It is soluble in water and soluble in organic solvents such as alcohols, ethers, etc.3. EDC hydrochloride is stable at room temperature.Use:1. EDC hydrochloride is a commonly used chemical reagent and has a wide range of applications in organic synthesis.2. As an activator: EDC hydrochloride can react with amino acids or peptide bonds to generate acylated intermediates, thereby playing an important role in peptide synthesis and protein modification.3. As a coupling agent: EDC hydrochloride can conjugate acids and alcohols to form ester bonds, which are used to synthesize esters, ethers, and imides and other compounds.4. Used for the synthesis of dyes and pigments.Preparation method:EDC hydrochloride can be obtained by reacting EDC with hydrochloric acid. During the specific operation, EDC is mixed with a sufficient amount of hydrochloric acid solution, stirred and heated to obtain the crystallization of EDC hydrochloride by evaporating the solvent.Safety Information:1. EDC hydrochloride may have irritating effects on the skin, eyes and respiratory tract, so protective gloves, goggles and masks should be worn.2. Avoid direct inhalation or contact with EDC hydrochloride powder.3. When using EDC hydrochloride, pay attention to good indoor ventilation to avoid inhaling its volatile gases.4. When handling EDC hydrochloride, care should be taken to prevent it from being swallowed or accidentally ingested.5. It should be stored in a dry place away from heat sources, and avoid contact with oxidants and flammable materials.
