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2-Amino-3,5-dibromo-6-methylpyridine (C6H6Br2N2, CAS: 91872-10-5) is a bi-brominated, methyl-substituted pyridine derivative systematically named 3,5-dibromo-6-methylpyridin-2-amine. It has a molecular weight of 265.93 g/mol and is recognized as one of the most valuable multi-halogenated heterocyclic building blocks in modern synthetic chemistry. The structure features a central pyridine ring carrying an electron-donating primary amine group (-NH2) at the C2 position, an electron-withdrawing methyl substituent at C6, and two strategically placed bromine atoms at C3 and C5. This carefully engineered substitution pattern—electron-rich amino site paired with two electrophilic bromine leaving groups—creates a uniquely versatile bifunctional reactivity profile that enables orthogonal diversification: the C2 amino group allows for amide coupling, Schiff base formation, and heterocyclic annulation, while the C3 and C5 bromine atoms enable sequential nucleophilic aromatic substitution (SNAr) and transition metal-catalyzed cross-couplings (Suzuki-Miyaura, Buchwald-Hartwig, Ullmann, Sonogashira) under mild conditions without intermediate protection steps. The three independent reactive handles make this compound a high-density information-rich scaffold that serves as the ideal starting point for convergent synthesis strategies.

This synthetic versatility positions 2-amino-3,5-dibromo-6-methylpyridine as a critical building block across three major high-value industrial sectors: pharmaceutical intermediate for the synthesis of antimicrobial APIs and central nervous system (CNS) agents; essential structural scaffold for developing highly potent heterocyclic agrochemicals (pesticides, herbicides, fungicides); and a uniquely functionalized platform for material science applications requiring distinct electronic properties.

Core Application Fields and Market Demand

Market demand for 2-amino-3,5-dibromo-6-methylpyridine is rapidly expanding and strongly concentrated in three major end-use sectors: Pharmaceutical R&D (≈50% of total consumption), Agrochemical Development (≈35%), and Specialty Chemical & Material Science (≈15%). The compound‘s role as a key intermediate in synthesizing bioactive molecules, antimicrobial agents, and CNS active pharmaceutical ingredients accounts for the majority of growth in the pharmaceutical segment. Global pyridine and pyridine derivatives market was valued at USD 1.38 billion in 2025 and is projected to grow at a robust CAGR of 7.43% to reach USD 2.64 billion by 2034, driven by the increasing role of heterocyclic building blocks in drug discovery and precision agriculture formulations. Within this broader category, the specialized halogenated pyridine subsegment is expanding even faster, with the global halogenated pyridine market valued at approximately USD 1.19-1.26 billion in 2025 and projected to reach USD 1.79-1.92 billion by 2032, exhibiting a CAGR of 6.0-6.3%. Heterocyclic intermediates, including pyridines, pyrimidines and halopyridines, now account for over 40% of the global specialty intermediate market, underscoring the strategic importance of this well‑differentiated scaffold. The compound‘s unique pattern of two bromine atoms flanking the C6 methyl group gives it superior reactivity characteristics compared to simpler halogenated pyridines, justifying its premium position in the C6‑brominated pyridine niche.

1. Pharmaceutical R&D (≈50% of total demand).

This compound serves as a versatile key intermediate in the synthesis of diverse pharmaceutical candidates, performing multiple distinct roles across various therapeutic areas:

Antimicrobial Development: It serves as a key intermediate in the synthesis of various pharmaceuticals, particularly in the development of antimicrobial agents. The dual bromine substituents and the C6 methyl group create a sterically and electronically optimized platform that facilitates rapid library synthesis for SAR exploration against drug-resistant bacterial strains.
Antiviral API Synthesis: It acts as a reagent in the synthesis of imidazopyridines as antiviral agents, where the 3,5-dibromo pattern provides the necessary electronic modulation for target engagement with viral polymerases and proteases.
CNS Agent Synthesis: The primary application of this compound lies in pharmaceutical research and development, particularly in the synthesis of bioactive molecules and central nervous system agents. The methyl group at C6 contributes to improved blood-brain barrier permeability, while the amino group serves as an attachment point for CNS-targeting pharmacophores.
Enzyme Inhibition Platforms: It acts as a reagent in the synthesis of amino(aryl)pyrazines as inhibitors of human lactate dehydrogenase, an emerging target in cancer metabolism and infectious disease therapy. The specific substitution pattern of this compound provides superior binding geometry for the LDH active site.
Antihistamine and Anti-inflammatory Intermediates: It is used as an intermediate for the preparation of anti-histamines and anti-inflammatory agents. The brominated pyridine core serves as a rigid spacer that orients pharmacophoric groups optimally for histamine receptor binding.
Peptide Synthesis: It is used in peptide synthesis for the preparation of active esters, where the electron-deficient pyridine ring activates the leaving group for efficient acylation reactions under mild conditions.

2. Agrochemical Development (≈35% of total demand).

2-Amino-3,5-dibromo-6-methylpyridine is a critical building block for the next generation of heterocyclic crop protection agents:

Heterocyclic Agrochemical Precursor: It is used in the formulation of agrochemicals, where the brominated pyridine core serves as an ideal precursor for highly potent pesticides and herbicides. The presence of both nucleophilic (NH2) and electrophilic (C-Br) sites allows for convergent assembly of complex heterocyclic frameworks. Heterocyclic intermediates like this compound are now a critical component of modern agrochemical discovery, with over 40% of new patented active ingredients containing a pyridine, pyrimidine or halopyridine moiety.
Herbicide & Fungicide Development: Through successive cross-coupling reactions at the C3 and C5 positions, followed by functionalization of the C2 amine, the compound can be rapidly converted into libraries of herbicidal and fungicidal candidates with high selectivity for plant vs. mammalian targets.

3. Material Science & Specialty Chemicals (≈15% of total demand).

The compound‘s ability to undergo orthogonal cross-coupling reactions without protecting-group chemistry makes it valuable for constructing functionalized π-conjugated systems:

Optoelectronic Materials: The compound is explored for its potential in creating novel materials with specific electronic properties, useful in the development of sensors and electronic devices.
Specialty Dyes: It finds application in the production of specialized dyes, particularly in the textile industry, providing vibrant colors with excellent stability.

Major Market Participants

The global supply system for 2-amino-3,5-dibromo-6-methylpyridine follows a pattern of “specialized fine chemical and pharmaceutical intermediate manufacturers, with production and R&D supply concentrated in China, India, Europe, Japan, and North America.” The compound is generally supplied as a light yellow to yellow crystalline powder with purity ranging from ≥97% to ≥99% (GC/HPLC), reflecting the growing demand for high-purity halogenated heterocycles.

A representative list of major suppliers includes: Sigma-Aldrich (97% purity, USP grade), TCI Chemicals (>98.0%(GC)(T) purity, high‑purity R&D grade), Capot Chemical (98%(Min,HPLC), industrial and R&D grade), Bidepharm (standard purity 98%, with full analytical release including HPLC, GC and NMR), BOC Sciences (research chemical, custom synthesis grade), Chem-Impex (≥99% (HPLC), high‑purity R&D), BenchChem, MolCore (NLT 98%), Aladdin, J&K Scientific, and others. Several Chinese companies, including XinChem, have established industrial-scale production capacities for this compound, serving both domestic and export markets. The compound can be supplied in research R&D quantities (1 g, 5 g, 10 g, 25 g, 100 g, 500 g) and industrial bulk scales (1 kg, 5 kg, 10 kg, 25 kg, multi‑kg).

Regional Market Dynamics

Global demand for 2-amino-3,5-dibromo-6-methylpyridine shows a clear regional pattern: Asia-Pacific is the largest and fastest‑growing region, North America and Europe lead in high‑purity R&D and pharmaceutical applications, and Latin America & Middle East/Africa follow as emerging growth markets.

Asia-Pacific, and particularly China, has emerged as the dominant manufacturing hub for halogenated pyridine intermediates. Chinese manufacturers have optimized large-scale bromination and purification processes, producing high-purity material at highly competitive prices. These facilities are increasingly GMP-compliant and hold ISO certifications, enabling them to serve the regulated pharmaceutical markets. India‘s rapidly expanding generic agrochemical and pharmaceutical API sector also drives significant volume demand. North America and Europe command the largest share of high-purity R&D consumption (≥99 %), driven by the highest concentration of antimicrobial and CNS drug discovery programs and agrochemical innovation centers. Customer requirements in these regions are stringent: purity ≥99 %, full traceability, ICH Q3D compliance for heavy metals, full impurity profiling including residual solvents and related substances by HPLC‑UV, and cGMP documentation for pharmaceutical use. Japan and South Korea demand ultra‑high‑purity grades for advanced drug development and high‑performance agrochemical formulations.

Regulatory and Environmental Considerations

2-Amino-3,5-dibromo-6-methylpyridine (CAS 91872-10-5) is a halogenated organic compound requiring careful handling and regulatory compliance for commercial use. It is classified as an irritant (Xi) with risk codes R36/37/38 (“Irritating to eyes, respiratory system and skin”). Hazard statements include H315 (causes skin irritation), H319 (causes serious eye irritation), H335 (may cause respiratory irritation). The compound is also classified with R20/21/22 (Harmful by inhalation, in contact with skin and if swallowed). Personal protective equipment (PPE) including chemical‑resistant gloves, safety glasses, and respiratory protection (dust mask type N95) is required during handling. Storage conditions: keep in dark place, under inert atmosphere (nitrogen or argon) at room temperature (2-8°C recommended for long‑term storage), in tightly sealed containers away from light, strong oxidizing agents, and strong acids. The compound is stable for up to three years when stored as a powder at -20°C and for up to two years at 2-8°C. Solutions in DMSO are stable for up to one year at -80°C. Transport is subject to ADR/RID/IMDG regulations for Class 9 (miscellaneous hazardous materials), with proper packaging to ensure product integrity during logistics. In the EU, the compound is subject to REACH regulations; importers and manufacturers must provide Safety Data Sheets (SDS). In the US, it is regulated under TSCA as a research chemical; for use in pharmaceutical API synthesis, adherence to cGMP guidelines (21 CFR Parts 210/211) is required. In China, the compound is listed in the Inventory of Existing Chemical Substances (IECSC), with customs HS Code 29333990 (heterocyclic compounds with nitrogen hetero‑atom(s) only) and requires safety production licenses for manufacturing facilities.

Future Outlook

The market outlook for 2-amino-3,5-dibromo-6-methylpyridine is tied to four core drivers: (1) the sustained global demand for novel antimicrobial agents, with the pipeline of candidates targeting drug-resistant bacteria, viruses, and fungi continuing to expand; (2) the explosive growth in CNS drug discovery, where heterocyclic scaffolds with optimal lipophilicity for blood-brain barrier penetration are in high demand; (3) the rapid growth of Asian CRO/CDMO sectors supplying intermediates to global pharmaceutical and agrochemical companies; and (4) the increasing adoption of this compound as a uniquely functionalized platform for material science applications and specialty chemical synthesis. Enterprises should focus on securing high‑purity (≥99 %) production capabilities, maintaining rigorous impurity documentation (including residual solvents, heavy metals by ICP‑MS, and related substances) for global regulatory filings, and building long‑term supply partnerships with pharmaceutical API manufacturers, agrochemical formulators, and research institutions.

Shanghai XinChem Co., Ltd. (XinChem)

As a world‑leading supplier of pharmaceutical intermediates, halogenated heterocyclic building blocks, and agrochemical precursors, Shanghai XinChem Co., Ltd. (XinChem) has always focused on the innovative needs of the antimicrobial API manufacturing, CNS drug discovery, and crop protection industries. Relying on core advantages in multi‑step heterocyclic bromination, Suzuki‑Miyaura cross‑coupling optimization, purification, and quality assurance, we provide high‑quality 2-Amino-3,5-dibromo-6-methylpyridine (CAS 91872-10-5) to global customers.

1. Technical Advantages

High Purity & Consistency: Our product achieves purity ≥98‑99 % (GC/HPLC), light yellow to yellow crystalline powder, molecular weight 265.93 g/mol, moisture <0.5 % (KF titration), and melting point 143.5‑148.5 °C. MDL number MFCD00068229, PubChem ID 522994.
Low Impurity Profile: Strict control of residual solvents (<0.5 % total), heavy metals (≤10 ppm, Pb, As, Cd, Hg, ICH Q3D compliant), and related substances by HPLC‑UV ensures high synthetic performance for API and agrochemical manufacturing.
Orthogonal Functional Group Compatibility: The C2 amino group is fully compatible with amide coupling, Schiff base formation, and heterocyclic annulation; the C3 and C5 bromine atoms are optimized for sequential SNAr reactions and transition metal‑catalyzed cross‑couplings (Suzuki‑Miyaura, Buchwald‑Hartwig, Sonogashira, Ullmann), enabling divergent synthesis strategies without intermediate protection steps.
Batch‑to‑Batch Uniformity: Rigorous analytical testing (GC, HPLC, NMR, LC‑MS, heavy metals by ICP‑MS, residual solvents by GC‑headspace, Karl Fischer titration) guarantees consistent quality and reproducible yields across all production lots.

2. Product Advantages

Premium Halogenated Pyridine Scaffold: Directly used as a key building block for antimicrobial APIs, CNS active agents, antiviral compounds (imidazopyridines), antihistamines, anti‑inflammatory APIs, and human lactate dehydrogenase inhibitors.
Agrochemical Core Intermediate: Essential precursor for highly potent pesticides, herbicides, and fungicides; heterocyclic crop protection formulations requiring rigid, electron‑deficient aromatic cores.
Material Science & Dye Applications: Building block for optoelectronic sensors and electronic devices; specialty textile dyes with excellent stability and vibrant coloration.
Scalable Multi‑Step Synthesis: Proven synthesis via bromination of 2-amino-6-methylpyridine with brominating agents under controlled conditions (temperature, concentration, reaction time); multi‑kg to metric‑ton scalability confirmed, enabling seamless transition from research grams to industrial‑scale manufacturing.
Flexible Packaging Options: 1 g, 5 g, 10 g, 25 g, 50 g, 100 g, 500 g glass bottles (R&D); 1 kg HDPE containers (pilot); 5 kg, 10 kg, 25 kg fiber drums (industrial). Full custom packaging available for pharmaceutical and agrochemical campaigns.
Reliable Supply Chain: Annual capacity in the multi‑metric‑ton range, with dedicated temperature‑controlled warehousing (2‑8 °C, dry, light‑protected, sealed containers) and just‑in‑time delivery capabilities.

3. Application Fields

Pharmaceutical Intermediates: Key building block for antimicrobial APIs (development of novel antibiotics against drug‑resistant strains), antiviral agents (imidazopyridine synthesis), CNS active agents, antihistamines, anti‑inflammatory drugs, and human lactate dehydrogenase inhibitors.
Agrochemical Intermediates: Core building block for highly potent pesticides, herbicides, fungicides, and specialty crop protection formulations requiring rigid heterocyclic cores.
Material Science & Optoelectronics: Functionalized π‑conjugated systems, sensors and electronic devices, specialty textile dyes, and advanced materials with engineered electronic properties.
Synthetic Chemistry: Orthogonal diversification platform via sequential cross‑coupling at C3 and C5 followed by C2 functionalization; building block for complex heterocyclic libraries, ligand synthesis, and catalyst development.
Peptide Synthesis: Precursor for active esters with enhanced reactivity for mild acylation reactions.

4. Service Support
Our technical team provides full impurity profiling (GC purity, HPLC‑UV related substances, residual solvents by GC‑headspace, heavy metals by ICP‑MS, LC‑MS identity confirmation), custom purification to any desired specification, and complete regulatory documentation (Certificate of Analysis, Technical Data Sheet, Safety Data Sheet, REACH compliance, TSCA certification, DMF support for pharmaceutical customers). We also offer custom synthesis of halogenated pyridine derivatives, cold‑chain logistics, and just‑in‑time delivery.

5. Why Choose XinChem

Professionalism: 20 + years in the pharmaceutical intermediate, halogenated heterocyclic synthesis, and fine chemical industries.
Flexibility: Tailored to customer purity specifications, packaging sizes, and regulatory documentation requirements.
Cost‑effectiveness: High purity at competitive industrial pricing.

Post time: Jun-01-2026

A Versatile Halogenated Scaffold for Advanced Pharmaceutical Synthesis and Agrochemical Development: 2-Amino-3,5-dibromo-6-methylpyridine (CAS 91872-10-5)