2-Mercaptothiophene（CAS#7774-74-5）
| Risk Codes | R21/22 - Harmful in contact with skin and if swallowed. R36/38 - Irritating to eyes and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | UN3334 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-13-23 |
| HS Code | 29349990 |
| Hazard Class | 9 |
| Packing Group | III |
2-Mercaptothiophene 2-Thiophenethiol Thiophene-2-thiol | CAS 7774 74 5
One Line Sourcing Position
High purity 2-Mercaptothiophene for flavor formulation, pharmaceutical intermediate, and organic synthesis applications.
Quick RFQ Form
Fill below to get instant quote:
Name Email Company Required quantity Delivery destination Submit
Specification
| Parameter | Specification |
|---|---|
| Purity by Iodometric Titration | 97.0 percent minimum, typical batch 98.0 to 99.0 percent |
| Appearance | Light yellow to brown clear liquid |
| Molecular Formula | C4H4S2 |
| Molecular Weight | 116.20 to 116.21 g per mol |
| Boiling Point | 129 degrees Celsius (lit.) or 166 degrees Celsius |
| Density | 1.252 g per mL at 25 degrees Celsius (lit.) |
| Refractive Index | 1.62 (lit.) |
| Flash Point | 65 degrees Celsius (149 degrees Fahrenheit) |
| Physical State (20 deg C) | Liquid |
| Solubility | Slightly soluble in water; soluble in alcohol and organic solvents |
| Storage Temperature | Refrigerated 0 to 10 degrees Celsius; store under inert gas |
| Condition to Avoid | Air sensitive, heat sensitive |
| Stock Status | In Stock in US warehouse and China hub |
Available Quantity and Lead Time
Regular supply: 100 g to 10 metric tons per shipment
Lead time: 3 to 5 days for standard packaging; bulk orders require 7 to 10 days
Document Support
COA SDS HPLC chromatogram NMR spectrum Mass spectrum MS available upon request
Application
2-Mercaptothiophene, also known as thiophene-2-thiol or 2-thienyl mercaptan, is a heteroaromatic thiol comprising a thiophene ring substituted at the 2-position with a sulfhydryl group. It is a versatile building block with broad applications across flavor, pharmaceutical, and chemical synthesis industries.
In the flavor industry, 2-mercaptothiophene is used as a flavoring agent for food products. It is approved as FEMA GRAS (No. 3062) and meets JECFA specifications (No. 1052), with no safety concern at current levels of intake when used as a flavoring agent. It is commonly used to blend food flavors, particularly for candy and baked goods flavoring. It is also listed in the FDA's EAFUS (Everything Added to Food in the United States) database.
In pharmaceutical and biochemical research, 2-mercaptothiophene is a potent inhibitor of epidermal growth factor (EGF). It has been shown to inhibit the growth of cancer cells in vitro and in vivo. It also has potent inhibitory activity against EGF-induced chloride ion currents and membrane depolarization. The compound binds with fatty acids, glutamate, and amines to form tautomers. It also inhibits the production of prostaglandins, which may play a role in its anti-inflammatory properties. It is used as a pharmaceutical intermediate and in biochemical research.
In organic synthesis, 2-mercaptothiophene serves as an intermediate in organic syntheses and as a building block for the preparation of various sulfur-containing heterocyclic compounds.
Custom Synthesis Support
We offer custom synthesis for 2-mercaptothiophene derivatives including substituted analogs, isotopically labeled versions, and higher purity grades (99.0 percent and above). Custom packaging under inert atmosphere is available. Share your technical datasheet for feasibility review.
Packaging and Shipping
Available in 5 g, 25 g, 100 g, 500 g, 1 kg, 5 kg, or 25 kg drums with PTFE lined caps. Custom packaging such as amber glass bottles under inert atmosphere is supported. Fastest dispatch within 7 days after order confirmation.
2-Mercaptothiophene is a hazardous material: UN 2810, Class 6.1 (Poison), Packing Group III. Store refrigerated at 0 to 10 degrees Celsius under inert gas (nitrogen or argon). The compound is air sensitive and heat sensitive. Keep away from strong oxidizing agents and ignition sources. Signal word: Danger. Hazard Statements: H301 + H311 + H331 Toxic if swallowed, in contact with skin or if inhaled; H315 Causes skin irritation; H319 Causes serious eye irritation.
Why XinChem
XinChem provides 2-mercaptothiophene with strict control of purity and impurity profile for US customers. Our ISO 9001 certified facility monitors every batch by iodometric titration and GC, ensuring consistent quality for flavor, pharmaceutical, and synthesis applications. We maintain a buffer stock in US warehouses for emergency deliveries within 48 hours. Each order includes a full documentation package: COA, SDS, and chromatograms accessible through our online portal. Our technical support team assists with handling under inert atmosphere, stability optimization, and regulatory compliance including TSCA, EINECS (231-881-1), FEMA GRAS No. 3062, JECFA No. 1052, and FDA EAFUS listing. For contract customers, we offer quarterly price locks and consignment inventory to reduce supply chain risk. Trusted by numerous flavor houses, pharmaceutical companies, and research institutions in North America. We also provide free sample evaluation for qualified R&D projects and a price match guarantee against any valid competitor quote for equivalent quality. All shipments are packaged under inert atmosphere to prevent oxidation, with clear handling instructions and appropriate hazard communication.
FAQ
Q1 How should 2-mercaptothiophene be stored to maintain its quality?
A Store refrigerated at 0 to 10 degrees Celsius under inert atmosphere (nitrogen or argon) in tightly closed containers. The compound is air sensitive and heat sensitive. Protect from light and strong oxidizing agents. Shelf life is 24 months under recommended conditions.
Q2 What purity grades do you supply?
A Standard grade is 97.0 percent minimum by iodometric titration. We also supply 98.0 percent and 99.0 percent grades for pharmaceutical and analytical reference applications upon request.
Q3 Is 2-mercaptothiophene soluble in water?
A It is slightly soluble in water. It is soluble in alcohol and most organic solvents.
Q4 Do you provide sample quantities for flavor development or research?
A Yes, free samples are available for qualified US companies. Shipping fee applies for small quantities.
Q5 Is 2-mercaptothiophene approved for use as a food flavoring?
A Yes, it is FEMA GRAS (No. 3062) and meets JECFA specifications (No. 1052), with no safety concern at current levels of intake when used as a flavoring agent. It is also listed in the FDA's EAFUS database. Please request our regulatory package for your specific application.
Q6 What are the main applications of 2-mercaptothiophene?
A Primary applications include: (1) flavoring agent for candy, baked goods, and food products; (2) pharmaceutical intermediate and biochemical research, including EGF inhibition studies; and (3) building block for organic synthesis and sulfur-containing heterocyclic compounds.
Q7 What safety precautions are required when handling 2-mercaptothiophene?
A 2-Mercaptothiophene is toxic if swallowed, in contact with skin, or if inhaled. It causes skin and serious eye irritation. Use in a fume hood with full PPE including chemical resistant gloves, safety goggles, and protective clothing. Avoid breathing vapors. Keep away from heat, sparks, and open flames. In case of contact, rinse immediately with plenty of water and seek medical attention.
