2,4-Difluorobenzylamine(CAS#72235-52-0)
2,4-Difluorobenzylamine (CAS 72235-52-0) is a high-value fluorinated organic amine with the molecular formula C₇H₇F₂N and molecular weight 143.13 g/mol. It appears as a colorless to pale yellow transparent liquid with a characteristic amine odor. The presence of two fluorine atoms at the 2 and 4 positions of the benzyl ring, combined with a reactive primary amine group (-CH₂NH₂), makes this compound an exceptionally versatile building block for pharmaceutical and agrochemical synthesis. Fluorination enhances metabolic stability, lipophilicity, and bioavailability of drug candidates—properties highly sought after in modern drug discovery.
As a leading difluorobenzylamine supplier and fluorinated intermediate manufacturer, Xinchem leverages deep fluorination chemistry expertise to deliver high purity (≥99.0%) 2,4-difluorobenzylamine. We support custom synthesis of fluorinated amines and derivatives, with ISO9001-certified quality and GMP-aligned manufacturing. Our product is designed for bulk/wholesale supply to global pharmaceutical, biotech, and agrochemical CDMOs.
Specifications
| Parameter | Specification |
|---|---|
| Product Name | 2,4-Difluorobenzylamine (2,4-DFBA) |
| CAS No. | 72235-52-0 |
| Molecular Formula | C₇H₇F₂N |
| Molecular Weight | 143.13 g/mol |
| IUPAC Name | (2,4-Difluorophenyl)methanamine |
| Appearance | Colorless to pale yellow clear liquid |
| Purity (GC) | ≥99.0% (Pharmaceutical grade) / ≥98.0% (Technical grade) |
| Density (25°C) | 1.180 g/cm³ (approx.) |
| Boiling Point | 70–72°C (at 10 mmHg) |
| Flash Point | 75°C (closed cup) |
| Refractive Index (nD20) | 1.492 |
| Water Content (KF) | ≤0.3% |
| Color (APHA) | ≤50 |
| Single Maximum Impurity | ≤0.5% |
| Total Impurities | ≤1.0% |
| EINECS No. | 615-496-3 |
| PubChem CID | 2733307 |
| InChI Key | KBGMAJPDLVCPQM-UHFFFAOYSA-N |
| HS Code (China Export) | 29214990 |
| UN Number | 2735 (Class 8, PG III) – Corrosive liquid, basic, organic, n.o.s. |
| Storage Conditions | Store in a cool, dry, well-ventilated place. Keep container tightly closed. Protect from air and moisture. |
| Shelf Life | 12 months under recommended storage |
Applications
| Application Sector | Key Uses |
|---|---|
| Pharmaceuticals (API Synthesis) | Key building block for antiviral drugs (e.g., HIV protease inhibitors, HCV NS3/4A inhibitors), anticancer agents (kinase inhibitors, PARP inhibitors), and CNS drugs. The difluorobenzylamine moiety is found in molecules such as fluvoxamine (SSRI antidepressant), voriconazole (antifungal), and various investigational compounds. |
| Agrochemicals | Used in the synthesis of modern fluorinated pesticides, including fungicides (e.g., fluopyram analogs), herbicides, and insecticides. Fluorine substitution improves environmental stability and target selectivity. |
| Peptide/Peptidomimetic Chemistry | Serves as a precursor for fluorinated benzylamine derivatives used in peptide modification and PROTAC (proteolysis-targeting chimera) linkers. |
| Fine Chemical Synthesis | Intermediate for manufacturing specialty amines, amides, Schiff bases, and heterocyclic compounds (e.g., benzimidazoles, quinazolines) with enhanced bioactivity. |
| Material Science | Used in the production of fluorinated polymers, liquid crystal displays (LCDs), and functional coatings requiring unique electronic properties. |
Supply Ability / CDMO Capabilities
Xinchem is a premier 2,4-difluorobenzylamine manufacturer with deep fluorination chemistry expertise and robust CDMO capabilities:
| Parameter | Capability |
|---|---|
| Annual Production Capacity | 200+ metric tons (expandable) |
| Purity Grade | Pharmaceutical grade (≥99.0% GC), Research grade (≥98.0%), Custom purity (up to 99.9%) |
| Custom Synthesis | Tailored substitution patterns (mono-, di-, trifluorinated benzylamines), isotopically labeled analogs (²H, ¹³C, ¹⁵N), derivative synthesis (amides, carbamates, sulfonamides, ureas, Schiff bases) |
| Process Development | Route optimization for cost-effective scale-up; continuous flow fluorination available |
| Packaging Options | 1 kg, 5 kg, 25 kg drum, 50 kg HDPE drum, 200 kg steel drum, custom packaging |
| MOQ (Bulk/Wholesale) | 100 g (R&D samples); 100 kg (bulk orders) |
| Lead Time | 3–5 days for in-stock; 14–21 days for custom synthesis |
| Export Markets | USA, EU (Germany, Switzerland, UK, France), Japan, South Korea, Russia, India |
| Logistics | Ambient or refrigerated shipping; professional handling of corrosive (Class 8) materials |
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• Official Website: www.xinchem.com
• Email: sales1@xinchem.com
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