2,4-Difluorobenzylamine(CAS#72235-52-0)

Chemical Property:

Name	2,4-Difluorobenzylamine
Synonyms	RARECHEM AL BW 0282 2,4-Fluorobenzylamine 2,4-DIFLUOROBENZYLAMINE 2,4-Difluorobenzylamine 2,4-Difluorobenzyl Amine 2,4-Difluorobenzenemethanamine (2,4-Difluorophenyl)methanamine Benzenemethanamine, 2,4-difluoro- 1-(2,4-difluorophenyl)methanamine (2,4-difluorophenyl)methanaminium 2,4-DIFLUOROBENZYLAMINE HYDROCHLORIDE
CAS	72235-52-0
EINECS	276-502-0
InChI	InChI=1/C7H7F2N/c8-6-2-1-5(4-10)7(9)3-6/h1-3H,4,10H2/p+1
InChIKey	QDZZDVQGBKTLHV-UHFFFAOYSA-N

72235-52-0 - Physico-chemical Properties

Molecular Formula	C7H7F2N
Molar Mass	143.13
Density	1.204 g/mL at 25 °C (lit.)
Melting Point	255-256 °C(Solv: N,N-dimethylformamide (68-12-2))
Boling Point	82-84 °C (15 mmHg)
Flash Point	155°F
Vapor Presure	1.02mmHg at 25°C
Appearance	Liquid
Specific Gravity	1.204
Color	Clear colorless to light yellow
BRN	3539259
pKa	8.58±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Sensitive	Air Sensitive
Refractive Index	n20/D 1.49(lit.)

72235-52-0 - Risk and Safety

Hazard Symbols	C – Corrosive
Risk Codes	34 – Causes burns
Safety Description	S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S27 – Take off immediately all contaminated clothing. S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S25 – Avoid contact with eyes.
UN IDs	UN 2735 8/PG 3
WGK Germany	3
HS Code	29214990
Hazard Note	Corrosive
Hazard Class	8
Packing Group	III

Send email to us

Product Detail

Product Tags

2,4-Difluorobenzylamine (CAS 72235-52-0) is a high-value fluorinated organic amine with the molecular formula C₇H₇F₂N and molecular weight 143.13 g/mol. It appears as a colorless to pale yellow transparent liquid with a characteristic amine odor. The presence of two fluorine atoms at the 2 and 4 positions of the benzyl ring, combined with a reactive primary amine group (-CH₂NH₂), makes this compound an exceptionally versatile building block for pharmaceutical and agrochemical synthesis. Fluorination enhances metabolic stability, lipophilicity, and bioavailability of drug candidates—properties highly sought after in modern drug discovery.

As a leading difluorobenzylamine supplier and fluorinated intermediate manufacturer, Xinchem leverages deep fluorination chemistry expertise to deliver high purity (≥99.0%) 2,4-difluorobenzylamine. We support custom synthesis of fluorinated amines and derivatives, with ISO9001-certified quality and GMP-aligned manufacturing. Our product is designed for bulk/wholesale supply to global pharmaceutical, biotech, and agrochemical CDMOs.

Specifications

Parameter	Specification
Product Name	2,4-Difluorobenzylamine (2,4-DFBA)
CAS No.	72235-52-0
Molecular Formula	C₇H₇F₂N
Molecular Weight	143.13 g/mol
IUPAC Name	(2,4-Difluorophenyl)methanamine
Appearance	Colorless to pale yellow clear liquid
Purity (GC)	≥99.0% (Pharmaceutical grade) / ≥98.0% (Technical grade)
Density (25°C)	1.180 g/cm³ (approx.)
Boiling Point	70–72°C (at 10 mmHg)
Flash Point	75°C (closed cup)
Refractive Index (nD20)	1.492
Water Content (KF)	≤0.3%
Color (APHA)	≤50
Single Maximum Impurity	≤0.5%
Total Impurities	≤1.0%
EINECS No.	615-496-3
PubChem CID	2733307
InChI Key	KBGMAJPDLVCPQM-UHFFFAOYSA-N
HS Code (China Export)	29214990
UN Number	2735 (Class 8, PG III) – Corrosive liquid, basic, organic, n.o.s.
Storage Conditions	Store in a cool, dry, well-ventilated place. Keep container tightly closed. Protect from air and moisture.
Shelf Life	12 months under recommended storage

Applications

Application Sector	Key Uses
Pharmaceuticals (API Synthesis)	Key building block for antiviral drugs (e.g., HIV protease inhibitors, HCV NS3/4A inhibitors), anticancer agents (kinase inhibitors, PARP inhibitors), and CNS drugs. The difluorobenzylamine moiety is found in molecules such as fluvoxamine (SSRI antidepressant), voriconazole (antifungal), and various investigational compounds.
Agrochemicals	Used in the synthesis of modern fluorinated pesticides, including fungicides (e.g., fluopyram analogs), herbicides, and insecticides. Fluorine substitution improves environmental stability and target selectivity.
Peptide/Peptidomimetic Chemistry	Serves as a precursor for fluorinated benzylamine derivatives used in peptide modification and PROTAC (proteolysis-targeting chimera) linkers.
Fine Chemical Synthesis	Intermediate for manufacturing specialty amines, amides, Schiff bases, and heterocyclic compounds (e.g., benzimidazoles, quinazolines) with enhanced bioactivity.
Material Science	Used in the production of fluorinated polymers, liquid crystal displays (LCDs), and functional coatings requiring unique electronic properties.

Supply Ability / CDMO Capabilities

Xinchem is a premier 2,4-difluorobenzylamine manufacturer with deep fluorination chemistry expertise and robust CDMO capabilities:

Parameter	Capability
Annual Production Capacity	200+ metric tons (expandable)
Purity Grade	Pharmaceutical grade (≥99.0% GC), Research grade (≥98.0%), Custom purity (up to 99.9%)
Custom Synthesis	Tailored substitution patterns (mono-, di-, trifluorinated benzylamines), isotopically labeled analogs (²H, ¹³C, ¹⁵N), derivative synthesis (amides, carbamates, sulfonamides, ureas, Schiff bases)
Process Development	Route optimization for cost-effective scale-up; continuous flow fluorination available
Packaging Options	1 kg, 5 kg, 25 kg drum, 50 kg HDPE drum, 200 kg steel drum, custom packaging
MOQ (Bulk/Wholesale)	100 g (R&D samples); 100 kg (bulk orders)
Lead Time	3–5 days for in-stock; 14–21 days for custom synthesis
Export Markets	USA, EU (Germany, Switzerland, UK, France), Japan, South Korea, Russia, India
Logistics	Ambient or refrigerated shipping; professional handling of corrosive (Class 8) materials