4-Bromo-2-iodopyridine(CAS#100523-83-9)
Introduction
4-Bromo-2-iodopyridine is an organic compound with the formula C5H2BrIN. The following is a description of the properties, uses, preparation and safety information of this compound:
Nature:
-Appearance: 4-Bromo-2-iodopyridine is a white to light yellow crystal or a powdery solid.
-Melting point: about 170-172 degrees Celsius.
-Boiling point: about 296 degrees Celsius.
-Density: about 2.17g/cm3.
-Solubility: Soluble in organic solvents such as ethanol, acetone and chloroform.
Use:
-Chemical research: 4-Bromo-2-iodopyridine can be used as an intermediate in organic synthesis and chemical research.
-Drug research and development: It is also used in the research and development of biological drugs and in the field of biomedicine.
-Other uses: Because 4-bromo-2-iodopyridine has a special structure, it also has certain applications in other fields such as material science.
Preparation Method:
There are many preparation methods of 4-bromo-2-iodopyridine, and a common method is obtained by the reaction of 2-bromopyridine and silver iodide. The preparation process requires strict control of reaction conditions and appropriate treatment and purification processes.
Safety Information:
-4-Bromo-2-iodopyridine is an organic compound, so general laboratory safety practices should be followed during use.
-It may be irritating to the eyes, skin and respiratory system, and care should be taken to avoid contact. In case of contact, rinse immediately with water and seek medical advice.
-When storing, it should be placed in a closed container, away from fire and oxidizing agents. It is also necessary to avoid contact with strong acids and strong bases.
-If you have specific questions about the use and handling of the substance, it is recommended to consult a chemical expert or relevant technician.
Application
4-Bromo-2-iodopyridine is a high-purity dihalogenated pyridine building block featuring orthogonal bromine and iodine leaving groups. The iodine at the 2-position undergoes preferential oxidative addition in palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Stille, Sonogashira, Buchwald-Hartwig), while the bromine at the 4-position allows subsequent selective functionalization under more forcing conditions. This unique reactivity enables stepwise construction of complex, highly substituted pyridine-based scaffolds. In medicinal chemistry, it is widely used to synthesize potent kinase inhibitors targeting cancer, inflammation, and autoimmune diseases (e.g., JAK, BTK, CDK, EGFR inhibitors), as well as antiviral and antibacterial agents. Its rigid, electron-deficient pyridine core enhances target binding affinity and metabolic stability. This intermediate also supports agrochemical development (herbicides, fungicides), functional materials (OLEDs, organic semiconductors), and ligand synthesis for catalysis. High purity ensures reproducible results in high-throughput screening, SAR studies, and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
