2-Bromo-4-iodo-pyridine(CAS#100523-96-4)
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| Hazard Note | Irritant |
Introduction
2-Bromo-4-iodopyridine is an organic compound. It is a colorless to light yellow crystalline solid. The following is an introduction to the properties, uses, preparation methods and safety information of the compound:Quality:- Appearance: Colorless to light yellow crystalline solid- Solubility: It has a certain solubility in organic solvents, such as chloroform, acetone, etc- The structure of 2-bromo-4-iodopyridine contains bromine and iodine, which has certain chemical reactivity activityUse:- As a reagent in organic synthesis, it can be used in the preparation of other compounds or complexes- In the dye and pigment industry, it can be used to synthesize organic pigmentsMethod:The preparation of 2-bromo-4-iodopyridine is generally carried out by organic synthesis methods:2,4-diiodopyridine is mixed with miscible solvents (such as chloroform, acetone, etc.) and hydrogen bromide is added. Subsequently, the reaction mixture is heated to an appropriate temperature, and after a certain reaction time, 2-bromo-4-iodopyridine is produced. By solvent evaporation or other methods, pure 2-bromo-4-iodopyridine product is obtained.Safety Information:2-Bromo-4-iodopyridine may be toxic and irritating, and proper laboratory safety practices need to be followed during handling. When using or storing, it is necessary to avoid contact with strong oxidants and strong acids to avoid possible dangerous reactions. When handling 2-bromo-4-iodopyridine, protective measures should be taken, such as wearing gloves and goggles.
Application
2-Bromo-4-iodopyridine (CAS 100523-96-4) is a highly valuable dihalogenated pyridine building block featuring orthogonal bromine and iodine leaving groups. The iodine at the 4-position reacts preferentially in palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Stille, Sonogashira, Buchwald-Hartwig) due to its faster oxidative addition, while the bromine at the 2-position enables subsequent or selective functionalization under harsher conditions. This unique reactivity profile allows for the stepwise construction of highly substituted pyridine-based scaffolds. In medicinal chemistry, it is widely used to synthesize kinase inhibitors (e.g., JAK, BTK, CDK, EGFR), antiviral agents, and antibacterial compounds. Its rigid, electron-deficient pyridine core enhances target binding affinity and metabolic stability. This scaffold also serves as a key intermediate for agrochemical development (herbicides, fungicides), functional materials (OLEDs, organic semiconductors), and ligands for catalysis. High purity ensures reproducible results in high-throughput screening, SAR studies, and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
