Methyl 5-bromoquinoline-2-carboxylate(CAS#1355174-78-5)

Introduction

Methyl 5-bromoquinoline-2-carboxylate is an organic compound.Quality:- Appearance: Yellow to orange-yellow crystals or powder.- Solubility: Slightly soluble in water, soluble in common organic solvents such as ethanol, dimethylformamide, dichloromethane, etc.Use:- Methyl 5-bromoquinoline-2-carboxylic acid can be used as an intermediate or reagent in organic synthesis.Method:The preparation of methyl 5-bromoquinoline-2-carboxylic acid can usually be carried out by the following steps:5-bromoquinoline is reacted with formic acid and dimethyl carbonate to produce the corresponding esterification products.The product is properly crystallized, filtered, and dried to obtain the target product.Safety Information:- Contact with skin or inhalation may cause irritation, and appropriate personal protective equipment should be used.- Avoid contact with strong oxidizing agents to avoid the production of combustible substances.

Application
Methyl 5-bromoquinoline-2-carboxylate (CAS 1355174-78-5) is a functionalized quinoline derivative featuring a bromine atom at the 5-position and a methyl ester at the 2-position. This versatile heterocyclic building block is widely used in medicinal chemistry and pharmaceutical research as a key intermediate for the synthesis of bioactive molecules, including kinase inhibitors (e.g., PI3K, EGFR, and mTOR inhibitors), antimalarial agents, and antibacterial compounds. The bromine enables efficient cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) to introduce diverse aryl, heteroaryl, or alkyl substituents, while the methyl ester provides a handle for hydrolysis to carboxylic acid or reduction to alcohol, allowing further derivatization. This scaffold also serves as a precursor for fluorescent probes, agrochemicals, and materials for organic electronics. Its rigid, planar structure enhances target binding affinity and metabolic stability. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity methyl 5-bromoquinoline-2-carboxylate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.