4-Hydroxy-6,7-dimethoxyqunioline(CAS#13425-93-9)

Introduction

4-Hydroxy-6,7-dimethoxyquinoline is an organic compound. It is a solid substance with a white crystalline form. The following is an introduction to the properties, uses, preparation methods and safety information of the compound:Quality:4-Hydroxy-6,7-dimethoxyquinoline is an aromatic alcohol with hydroxyl and methoxy substituents. It is stable at room temperature and soluble in some organic solvents such as ethanol and methanol. The compound is unstable to light, heat, and air, and care should be taken to prevent exposure to light or high temperatures.Use:Method:In the laboratory, the preparation of 4-hydroxy-6,7-dimethoxyquinoline is usually done by a synthetic route. A common method is to use 4-aminoquinoline as a raw material and carry out a multi-step reaction, including acylation, aminomethylation, and hydroxylation to obtain the target product.Safety Information:The safety of 4-hydroxy-6,7-dimethoxyquinoline has not been studied in detail. As an organic synthetic compound, it may be toxic or irritating to the human body. Appropriate laboratory safety measures, such as wearing protective gloves, glasses, and a lab coat, should be taken to ensure that the operation is carried out in a well-ventilated environment. In case of accidental contact or inhalation, seek medical attention promptly.

Application
4-Hydroxy-6,7-dimethoxyquinoline (CAS 13425-93-9, also known as 6,7-dimethoxyquinolin-4-ol) is a versatile quinoline derivative widely used in pharmaceutical development and organic synthesis. This compound serves as a key pharmaceutical intermediate for the synthesis of targeted anticancer drugs, notably as a core building block for the tyrosine kinase inhibitors Cabozantinib and Tivozanib used in renal cell carcinoma and other solid tumors. It also exhibits inherent biological activities, including antimalarial properties used to prepare 4-aminoquinolines for malaria treatment, as well as antihypertensive and monoamine oxidase (MAO) inhibitory effects that can lower blood pressure. In medicinal chemistry, this scaffold is employed to develop novel antimicrobial, anticancer agents, and kinase inhibitors (EGFR-TK). The hydroxyl group enables further functionalization to form carboxamides, esters, and other bioactive compounds with analgesic and antihypoxic properties. This high-purity quinoline building block is an essential tool for drug discovery and custom synthesis projects, with the 4-hydroxy-6,7-dimethoxy substitution pattern providing unique hydrogen-bonding capabilities and chemical reactivity. Xinchem offers custom synthesis and contract manufacturing of 4-Hydroxy-6,7-dimethoxyquinoline with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.