4-Chloro-7-azaindole(CAS#55052-28-3)
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| HS Code | 29339900 |
| Hazard Class | 6.1 |
| Packing Group | Ⅲ |
Introduction
4-chloro-7-azaindole, also known as CNI-13, is an organic compound. The following is an introduction to its nature, use, manufacturing methods and safety information:Quality:- Appearance: White or white-yellow crystalline powder.- Solubility: soluble in organic solvents such as chloroform, dichloromethane, insoluble in water.- Chemical properties: It is a heterocyclic compound with some stability and inertness.Use:- Chemical synthesis: It can be applied to the synthesis reaction of indole compounds.- Pesticides: can be used as raw materials for insecticides or herbicides.Method:The preparation of 4-chloro-7-azaindole can be carried out by the following reactions:- Pyrrole and chloroacetic acid are reacted in the presence of ammonium chloride to produce pyrrole 4-chloro-1-acetic acid.- Then, pyrrole 4-chloro-1-acetic acid is condensed with ammonia and acetaldehyde under alkaline conditions to form 4-chloro-7-azaindole.4. Safety Information:- It has an irritating effect on the eyes and skin, rinse with water immediately after contact.- Appropriate precautions should be taken during use, such as wearing gloves, protective clothing and protective eyewear.- Avoid inhaling dust and ensure that the operation is carried out in a well-ventilated area.- Avoid contact with oxidants and strong acids during storage and use to prevent possible dangerous reactions.
Application
4-Chloro-7-azaindole (4-Chloro-1H-pyrrolo[2,3-b]pyridine) is a versatile heterocyclic building block and a crucial pharmaceutical intermediate for drug discovery. As a privileged scaffold, it acts as a purine bioisostere with dual hydrogen-bonding motifs, enabling the design of potent kinase inhibitors including JAK, FGFR, PAK4, and PIM1 for targeted cancer and inflammation therapies. The C4-chloro handle facilitates regioselective functionalization via palladium-catalyzed cross-coupling (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) and nucleophilic aromatic substitution for rapid SAR exploration. Xinchem offers high-purity 4-Chloro-7-azaindole with reliable custom synthesis, custom chemical synthesis, and contract manufacturing, flexible from R&D to commercial tons. Contact us for a competitive quote and global supply.
