4-Bromo-7-azaindole(CAS#348640-06-2)

Introduction

4-Bromo-7-azaindole is an organic compound. It has the following properties:1. Appearance: 4-bromo-7-azaindole is a white or light yellow crystalline solid.2. Solubility: It is soluble in organic solvents such as ethanol, dimethyl sulfoxide and dichloromethane, and insoluble in water.4. Stability: It is relatively stable at room temperature, but it can be easily reacted by oxidants, strong acids and alkalis.Its use, 4-bromo-7-azaindole is often used as a catalyst or intermediate in organic synthesis. It can be used as a catalyst in some chemical reactions to facilitate the reaction. It can also be used in the synthesis of other compounds, such as indoles.4-Bromo-7-azaindole can be obtained by the reaction of indole with bromoacetyl under alkaline conditions.Safety Information: 4-Bromo-7-azaindole is a chemical that requires compliance with relevant safety operating procedures when used or handled. It can have an irritating effect on the eyes, skin, and respiratory system, contact with the skin and eyes should be avoided, and operation should be ensured in well-ventilated conditions. When in use, goggles, protective gloves and protective clothing should be worn. Use under unsuitable conditions may produce harmful gases or vapors, and should be avoided from inhalation or ingestion. In case of accidental contact or inhalation, wash immediately or seek medical attention.

Application
4-Bromo-7-azaindole (CAS 348640-06-2, 4-Bromo-1H-pyrrolo[2,3-b]pyridine) is a high‑purity heterocyclic building block extensively used in medicinal chemistry and drug discovery. Its rigid 7-azaindole core serves as a purine bioisostere, providing dual hydrogen‑bond donor/acceptor motifs that enhance target binding affinity for kinase ATP pockets. The bromine at the 4-position enables efficient palladium‑catalyzed cross‑coupling reactions (Suzuki‑Miyaura, Buchwald‑Hartwig, Sonogashira) and nucleophilic aromatic substitution, allowing rapid construction of diverse drug‑like libraries for structure‑activity relationship (SAR) studies. This scaffold is a key intermediate for synthesizing potent tyrosine kinase inhibitors, including those targeting fibroblast growth factor receptors (FGFRs) for cancer therapy, as well as inhibitors of CK1 (casein kinase 1) for circadian rhythm modulation. Its derivatives are also employed in developing antiviral, antibacterial, and anti‑inflammatory agents. Beyond pharmaceuticals, 4-Bromo-7-azaindole is utilized in agrochemical research (herbicides, pesticides) and in advanced materials such as organic semiconductors for flexible electronics and solar cells. High purity ensures reproducible results in high‑throughput screening and scalable GMP manufacturing. Xinchem offers reliable custom synthesis, custom chemical synthesis, and contract manufacturing of 4-Bromo-7-azaindole with flexible scaling from R&D to commercial tons. Contact us for a competitive quote.