4-Chloropyrrolo[2,3-d]pyrimidine(CAS#3680-69-1)

Introduction

4-Chloropyrrolo[2,3-d]pyrimidine is an organic compound. The following is an introduction to the properties, uses, preparation methods and safety information of the compound:Quality:- Appearance: 4-chloropiralo[2,3-d]pyrimidine is colorless to light yellow crystals or white powder.- Solubility: 4-chloropyrolo[2,3-d]pyrimidine is soluble in chloroform, dimethyl sulfoxide (DMSO) and ethanol.Use:- 4-Chloropyrolo[2,3-d]pyrimidine is an important intermediate in organic synthesis and can be used to synthesize various molecules containing this structure.Method:- 4-Chloropyrolo[2,3-d]pyrimidine can be synthesized by a variety of methods, one of which is to use 2,3-dichloropyridine as the starting material, and undergo esterification, dehydrochlorination, and dehydroxyhydrochlorination to obtain the target product.Safety Information:- 4-Chloroporolo[2,3-d]pyrimidine is irritating and irritating to the eyes.- Appropriate personal protective equipment, such as lab gloves and goggles, should be worn when using or handling the compound.- Avoid inhaling, ingestion, or contact with the skin and from entering water bodies or the environment.- When using this compound, refer to the detailed safety literature and follow good laboratory practices.

Application
4-Chloropyrrolo[2,3-d]pyrimidine (CAS 3680-69-1) is a key heterocyclic intermediate featuring a fused pyrrole-pyrimidine core with a reactive chlorine at the 4-position. As a purine bioisostere, it serves as a versatile scaffold in medicinal chemistry for the development of kinase inhibitors targeting JAK, BTK, CDK, and other families involved in cancer, inflammation, and autoimmune diseases. The chlorine atom enables site-selective nucleophilic aromatic substitution and cross-coupling reactions (Suzuki, Buchwald-Hartwig, Sonogashira), facilitating rapid structure-activity relationship studies. This building block is also utilized in the synthesis of antiviral agents, agrochemicals, and functionalized heterocycles. Its rigid, planar structure enhances target binding affinity and selectivity. High purity ensures reproducible biological assay results and scalable pharmaceutical synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of 4-chloropyrrolo[2,3-d]pyrimidine with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.