4-iodo-2-methoxypyridine(CAS# 98197-72-9)
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
Introduction
4-iodo-2-methoxypyridine is an organic compound with the chemical formula C6H5INO. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 4-iodo-2-methoxypyridine is a white to light yellow solid.
-Solubility: It is soluble in some organic solvents.
Use:
4-iodo-2-methoxypyridine has certain application value in organic synthesis, and is often used as an effective compound intermediate or reagent.
Preparation Method:
4-iodo-2-methoxypyridine can be prepared by the following methods:
-It can be prepared by nucleophilic substitution reaction between pyridine and methyl iodide under alkaline conditions.
-can also be obtained by the reaction of pyridine with cuprous iodide and then with methanol.
Safety Information:
- 4-iodo-2-methoxypyridine may be irritating to the eyes, skin and respiratory tract, so direct contact should be avoided when using it.
-Wear protective glasses and gloves when handling, and ensure that the operation is carried out under good ventilation.
-Hazardous properties: The compound has certain acute toxicity and irritation, and may cause harm to the environment.
-Storage: Store in a cool, dry place, away from fire and oxidizing agents.
Application
4-Iodo-2-methoxypyridine (CAS 98197-72-9) is a high-purity heteroaryl iodide featuring a methoxy group at the 2-position and an iodine atom at the 4-position of the pyridine ring. The C-I bond exhibits enhanced reactivity in palladium-catalyzed cross-coupling reactions such as Suzuki-Miyaura couplings, achieving up to 92% yield in demanding transformations. This superior reactivity is attributed to its distinct pKa (2.02±0.10) compared to bromo (3.76) or chloro analogs. As a strategic building block, it is widely used in medicinal chemistry for constructing kinase inhibitor libraries and PD-1/PD-L1 inhibitor development. The iodine handle enables selective functionalization while the methoxy group provides electronic modulation. It also serves as a precursor for generating reactive intermediates in mechanistic studies and new synthetic methodologies. High purity (98% HPLC) with validated batch-specific CoA ensures synthetic reproducibility. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this key intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.







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